tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate

Base Information

Chemical Name:tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate
CAS No.:1284183-67-0
Molecular Formula:C₂₉H₃₆ClN₃O₆
Molecular Weight:558.074
Hs Code.:

Synonyms:tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate

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Chemical Property of tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate

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Technology Process of tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate

There total 8 articles about tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1284183-66-9
tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hex-5-ynoate

: 1284183-67-0
tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate

Guidance literature:: With Wilkinson's catalyst; hydrogen; In tetrahydrofuran; at 20 ℃; for 16h; under 3040.2 Torr;
DOI:10.1039/c0ob00686f

Reference yield:

: 6119-12-6
1-(4-chlorophenyl)-3-pyrazolidinone

: 1284183-67-0
tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxygen; copper(l) chloride / N,N-dimethyl-formamide / 3 h / 20 °C

1.2: 1 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 4.5 h / 20 - 60 °C / Inert atmosphere

4.1: Wilkinson's catalyst; hydrogen / tetrahydrofuran / 16 h / 20 °C / 3040.2 Torr

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Wilkinson's catalyst; hydrogen; oxygen; caesium carbonate; triethylamine; copper(l) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 3.1: Sonogashira coupling;
DOI:10.1039/c0ob00686f

Reference yield:

: 1284183-64-7
methyl 2-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-iodophenyl(methoxy)carbamate

: 1284183-67-0
tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 4.5 h / 20 - 60 °C / Inert atmosphere

2: Wilkinson's catalyst; hydrogen / tetrahydrofuran / 16 h / 20 °C / 3040.2 Torr

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Wilkinson's catalyst; hydrogen; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1039/c0ob00686f