13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester

Base Information

• Chemical Name: 13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester
• CAS No.: 121942-45-8
• Molecular Formula: C₂₈H₅₀O₅SSi
• Molecular Weight: 526.854
• Mol file: 121942-45-8.mol

Synonyms:13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester

Chemical Property of 13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester

There total 6 articles about 13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

methyl 12-bromododecanoate (26825-95-6) + (3-Benzenesulfonyl-propoxy)-tert-butyl-dimethyl-silane (121942-44-7) → 13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester (121942-45-8)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane; 1) -20 deg C, 10 min, 2) 20 deg C, 2+20 h;

Reference yield:

12-bromododecanoic acid (73367-80-3) → 13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester (121942-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: 40 percent / LDA, n-BuLi, HMPT / tetrahydrofuran; hexane / 1) -20 deg C, 10 min, 2) 20 deg C, 2+20 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane;

Reference yield:

3-phenylsulfonylpropanol (25062-90-2) → 13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester (121942-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / DMAP, Et₃N / CH₂Cl₂ / 1) 0 deg C, 30 min, 2) r.t, 1 h

2: 40 percent / LDA, n-BuLi, HMPT / tetrahydrofuran; hexane / 1) -20 deg C, 10 min, 2) 20 deg C, 2+20 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

methyl 12-bromododecanoate

(3-Benzenesulfonyl-propoxy)-tert-butyl-dimethyl-silane

12-bromododecanoic acid

3-phenylsulfonylpropanol

Downstream raw materials:

pentadecanolide