25062-90-2

Usage

Physical state

Colorless liquid

Solubility

Soluble in water

Uses

Reagent in organic synthesis, production of pharmaceuticals and agrochemicals, manufacturing of perfumes and flavorings, solvent in various chemical processes

Medical applications

Potential use as a prostaglandin inhibitor for the development of new therapeutic agents.

Upstream product

• 3112-85-4 methylphenylsulfonate 
• 75-07-0 acetaldehyde 
• 16212-05-8 (allylsulfonyl)benzene 
• 107-18-6 allyl alcohol 
• 80-17-1 benzenesufonyl hydrazide 
• 24536-40-1 3-phenylthiopropanol 
• 873-55-2 sodium benzenesulfonate 
• 627-18-9 1-bromo-3-propanol 
• 108-98-5 thiophenol 
• 930-69-8 sodium thiophenolate 
• 27098-65-3 3-phenylsulfanyl-propionaldehyde 
• 111086-99-8 2-(3-Phenylsulfanyl-propoxy)-tetrahydro-pyran 
• 67-56-1 methanol 
• 1121-30-8 1-hydroxy-2(1H)-pyridinethione 

Downstream Products

• 60012-77-3 Phenylsulfonyl-3-nonoanol-1 
• 60012-76-2 Phenylsulfonyl-3-heptanol-1 
• 60012-78-4 Phenylsulfonyl-⁽³⁾-undecanol-1 
• 60012-79-5 Phenylsulfonyl-⁽³⁾-methyl-⁽⁶⁾-hepten-⁽⁵⁾-ol-1 
• 144343-19-1 3-Benzenesulfonyl-octan-1-ol 
• 144343-21-5 3-Benzenesulfonyl-pentadecan-1-ol 
• 141642-37-7 1-mesyloxy-3-phenylsulfonylpropane 
• 144343-23-7 3-Benzenesulfonyl-hex-5-en-1-ol 
• 144343-22-6 3-Benzenesulfonyl-6-methyl-heptan-1-ol 
• 121942-45-8 13-Benzenesulfonyl-15-(tert-butyl-dimethyl-silanyloxy)-pentadecanoic acid methyl ester 
• 65288-11-1 3-(phenylsulfonyl)propyl p-toluenesulfonate 
• 187161-39-3 1-(3-chloropropylsulfonyl)-3-nitrobenzene 
• 1421917-98-7 1-(3-fluoropropylsulfonyl)-3-nitrobenzene 
• 1421917-99-8 3-(3-chloropropylsulfonyl)aniline 

Relevant academic research and scientific papers

Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis

Oxygenation is a fundamental transformation in synthesis. Herein, we describe the selective late-stage oxygenation of sulfur-containing complex molecules with ground-state oxygen under ambient conditions. The high oxidation potential of the active uranyl cation (UO22+) enabled the efficient synthesis of sulfones. The ligand-to-metal charge transfer process (LMCT) from O 2p to U 5f within the O=U=O group, which generates a UV center and an oxygen radical, is assumed to be affected by the solvent and additives, and can be tuned to promote selective sulfoxidation. This tunable strategy enabled the batch synthesis of 32 pharmaceuticals and analogues by late-stage oxygenation in an atom- and step-efficient manner.

Sulfoxide and sulfone compounds, as well as selective synthesis method and application thereof

The invention discloses a method for selectively synthesizing a sulfoxide compound shown as a formula (II) and a sulfone compound shown as a formula (III). In a reaction solvent, thioether (I) is usedas a reaction raw material and oxygen as an oxidation reagent, under the catalytic action of visible light and a photosensitive reagent; under the assistance of an additive, when a large-polarity proton-containing additive such as an acid and an alcohol or a solvent or an additive with excellent electron donating ability is used, a sulfoxide compound (II) is selectively generated; and when a small-polarity aprotic additive or a solvent is used, a sulfone compound (III) is selectively generated. The synthesis method has the advantages of easily available and cheap raw materials, simple reaction operation, mild reaction conditions, high yield and excellent functional group tolerance. According to the invention, synthesis and modification of some medicines are realized, and an efficient method for selectively constructing sulfoxide and sulfone compounds is provided for medicinal chemistry research.

Synthesizing method of 3-sulfonyl alcohol compounds

The invention discloses a synthesizing method of 3-sulfonyl alcohol compound. The method includes: using substituted sulfohydrazide and propenol compounds as the raw materials to perform reaction in water so as to obtain the 3-sulfonyl alcohol compounds. The method has the advantages that the method uses the substituted sulfohydrazide and the propenol compounds as the raw materials to perform the heating reaction in an aqueous solution without catalysts to directly obtain the 3-sulfonyl alcohol compounds, and the 3-sulfonyl alcohol compounds with the purity being above 80% can be obtained through simple separation after the reaction; the method is few in steps, simple to operate and green, and a new method for synthesizing medical and chemical alcohol compounds is provided for the chemical synthesizing field.

Design of a New Bimetallic Catalyst for Asymmetric Epoxidation and Sulfoxidation

A new chiral tethered 8-quinolinol-based ligand class is developed. The binuclear titanium complex of the ligand operates through a novel mechanism allowing for the regio- and stereoselective epoxidation of primary and tertiary homoallylic alcohols (up to 98% ee), as well as first examples of 2-allylic phenols (up to 92% ee). The new catalyst system also promotes the asymmetric oxidation of γ-hydroxypropyl sulfides giving an important class of chiral sulfoxides that have been inaccessible to date (up to 95% ee).

Fluorine-18 Radiolabeling and Radiopharmacological Characterization of a Benzodioxolylpyrimidine-based Radiotracer Targeting the Receptor Tyrosine Kinase EphB4

Members of the Eph receptor tyrosine kinase family play essential roles in the pathogenesis of cancer and are therefore promising candidates for molecular imaging by positron emission tomography (PET), for example. In this regard, radiochemical access to

Catalytic asymmetric hydroboration of heterofunctional allylic substrates: an efficient heterogenized version

The hydroboration of heterofunctional allylic systems with catecholborane (HBcat) using neutral and cationic rhodium complexes modified with P-P and P-N bidentate chiral ligands has been described in order to produce the secondary heteroorganoboronate ester as a major product with moderate enantioselectivity. The immobilization of cationic chiral rhodium complexes onto clays has beneficial effects on the recyclability and reuse of the catalytic system in particular for the hydroboration of allyl aryl sulfones.

The active role of NHC ligands in platinum-mediated tandem hydroboration-cross coupling reactions

Stable N-heterocyclic platinum-carbene complexes are the first example of platinum-mediated regioselective H-B addition to vinylarenes and alkynes, allowing consecutive cross coupling reactions with the same catalytic system. The Royal Society of Chemistry.

Selective oxidation of sulfides to sulfoxides and sulfones at room temperature using H2O2 and a Mo(VI) salt as catalyst

Selective oxidation of sulfides to sulfoxides and sulfones is achieved by H2O2 using MoO2Cl2 as the catalyst. Various substituted sulfides having functional groups such as methyl, methoxy, bromo, nitro, alkene, alkyne, alcohol, ester, aldehyde and remarkably an oxime are successfully and selectively oxidized without affecting the sensitive functionalities.

Heterofunctional control of regio- and enantioselectivity in rhodium-catalysed hydroboration of allylic systems

Aryl allylic sulfones were reacted with catecholborane (HBcat) in the presence of neutral and cationic Rh complexes modified with bidentate chiral ligands, to produce the branched heteroorganoboronate ester, as the main isomer with moderate enantioselecti

THIOL SULFONE METALLOPROTEASE INHIBITORS

This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.