Technology Process of C66H66N6O4
There total 5 articles about C66H66N6O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
dihydroquinine;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 2h;
Inert atmosphere;
(5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
Inert atmosphere;
DOI:10.1016/j.tet.2011.08.070
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
DOI:10.1016/j.tet.2011.08.070
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen bromide / water / Reflux
2.1: tetrabutylammomium bromide; sodium hydroxide / water / 0.25 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
With
tetrabutylammomium bromide; hydrogen bromide; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; water; mineral oil;
DOI:10.1016/j.tet.2011.08.070
