Technology Process of 5-(benzyloxy)-6-(difluoromethoxy)-1H-indole
There total 4 articles about 5-(benzyloxy)-6-(difluoromethoxy)-1H-indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(E)-2-(benzyloxy)-1-(difluoromethoxy)-4-(2-nitrovinyl)benzene;
With
nitric acid; acetic acid;
In
dichloromethane;
at 75 ℃;
for 3.91667h;
Cooling with ice;
With
iron; acetic acid;
In
ethanol; water;
at 70 ℃;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water; N,N-dimethyl-formamide / 2 h / 120 °C
2.1: potassium carbonate / acetonitrile / 3 h / 20 °C
3.1: acetic acid; ammonium acetate / 3 h / 130 °C / Inert atmosphere
4.1: acetic acid; nitric acid / dichloromethane / 3.92 h / 75 °C / Cooling with ice
4.2: 1 h / 70 °C / Inert atmosphere
With
ammonium acetate; nitric acid; potassium carbonate; acetic acid; sodium hydroxide;
In
dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 3 h / 20 °C
2.1: acetic acid; ammonium acetate / 3 h / 130 °C / Inert atmosphere
3.1: acetic acid; nitric acid / dichloromethane / 3.92 h / 75 °C / Cooling with ice
3.2: 1 h / 70 °C / Inert atmosphere
With
ammonium acetate; nitric acid; potassium carbonate; acetic acid;
In
dichloromethane; acetonitrile;
