N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine

Base Information

• Chemical Name: N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine
• CAS No.: 1174638-38-0
• Molecular Formula: C₂₂H₁₈N₂O₄S
• Molecular Weight: 406.462
• Mol file: 1174638-38-0.mol

Synonyms:N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine

Chemical Property of N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine

There total 2 articles about N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-benzyl-p-toluenesulfonamide (1576-37-0) + 1,1-dibromo-2-(3-nitrophenyl)ethene (444681-65-6) → N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine (1174638-38-0)

Guidance literature:

With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 60 ℃; for 24h; regioselective reaction; Inert atmosphere;

Reference yield:

N-benzyl-p-toluenesulfonamide (1576-37-0) + 1-bromo-2-(3-nitrophenyl)acetylene (86440-77-9) → N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine (1174638-38-0)

Guidance literature:

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; In toluene; at 70 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201915522

Reference yield:

N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine (1174638-38-0) + 4-methoxy-aniline (104-94-9) + phenylboronic acid (98-80-6) → (Z)-N-benzyl-N-(1-(4-methoxyphenyl)-2-(3-nitrophenyl)-2-phenylvinyl)-4-methylbenzenesulfonamide

Guidance literature:

4-methoxy-aniline; With tetrafluoroboric acid; tert.-butylnitrite; In ethanol; at 0 - 20 ℃; for 0.5h; Schlenk technique;

N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine; phenylboronic acid; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium hydrogencarbonate; In dimethyl sulfoxide; at 25 ℃; Schlenk technique;

DOI:10.1002/anie.201915522

upstream raw materials:

N-benzyl-p-toluenesulfonamide

1,1-dibromo-2-(3-nitrophenyl)ethene

1-bromo-2-(3-nitrophenyl)acetylene