6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Base Information

Chemical Name:6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CAS No.:1268476-89-6
Molecular Formula:C₂₈H₃₃F₃N₄O₆
Molecular Weight:578.588
Hs Code.:

6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Synonyms:6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Chemical Property of 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Technology Process of 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

There total 9 articles about 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1186231-83-3
6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

: 1268476-89-6
6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 10 - 35 ℃; for 5h; Cooling;

Reference yield:

: 1186188-72-6
ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

: 1268476-89-6
6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol / 1 h / 60 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 10 - 35 °C / Cooling

3: sodium tetrahydroborate / ethanol; tetrahydrofuran / 5 h / 10 - 35 °C / Cooling

With sodium tetrahydroborate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 30414-53-0
methyl propanoyl acetate

: 1268476-89-6
6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-5-(2-hydroxy-2-phenylethyl)-1-methyl-4-oxo-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: ammonium acetate / methanol / 72 h / 10 - 35 °C

2: sodium ethanolate / ethanol / 15 h / 150 °C

3: trichlorophosphate / 0.5 h / 80 °C

4: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C

5: triethylamine / ethanol / 25 h / 80 - 100 °C

6: caesium carbonate / dimethyl sulfoxide / 5 h / 100 °C

7: sodium hydroxide; water / ethanol / 1 h / 60 °C

8: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 10 - 35 °C / Cooling

9: sodium tetrahydroborate / ethanol; tetrahydrofuran / 5 h / 10 - 35 °C / Cooling

With sodium tetrahydroborate; ammonium acetate; water; sodium ethanolate; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;