4-[2-(2-carboxy-ethyl)-3-{7-[5-dimethylcarbamoyl-3'-fluoro-biphenyl-3-yl]-hept-6-ynyl}-phenoxy]-butyric acid

Base Information

Chemical Name:4-[2-(2-carboxy-ethyl)-3-{7-[5-dimethylcarbamoyl-3'-fluoro-biphenyl-3-yl]-hept-6-ynyl}-phenoxy]-butyric acid
CAS No.:1162261-49-5
Molecular Formula:C₃₅H₃₈FNO₆
Molecular Weight:587.688
Hs Code.:

Synonyms:4-[2-(2-carboxy-ethyl)-3-{7-[5-dimethylcarbamoyl-3'-fluoro-biphenyl-3-yl]-hept-6-ynyl}-phenoxy]-butyric acid

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Chemical Property of 4-[2-(2-carboxy-ethyl)-3-{7-[5-dimethylcarbamoyl-3'-fluoro-biphenyl-3-yl]-hept-6-ynyl}-phenoxy]-butyric acid

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Technology Process of 4-[2-(2-carboxy-ethyl)-3-{7-[5-dimethylcarbamoyl-3'-fluoro-biphenyl-3-yl]-hept-6-ynyl}-phenoxy]-butyric acid

There total 18 articles about 4-[2-(2-carboxy-ethyl)-3-{7-[5-dimethylcarbamoyl-3'-fluoro-biphenyl-3-yl]-hept-6-ynyl}-phenoxy]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1162261-42-8
4-[3-{7-[3-bromo-5-dimethylcarbamoyl-phenyl]-hept-6-ynyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric acid

: 768-35-4
3-fluorophenylboronic acid

: 1162261-49-5
4-[2-(2-carboxy-ethyl)-3-{7-[5-dimethylcarbamoyl-3'-fluoro-biphenyl-3-yl]-hept-6-ynyl}-phenoxy]-butyric acid

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; at 78 ℃; for 5h;

Reference yield:

: 56359-23-0
4-(2,3-dimethylphenoxy)butyric acid ethyl ester

: 1162261-49-5
4-[2-(2-carboxy-ethyl)-3-{7-[5-dimethylcarbamoyl-3'-fluoro-biphenyl-3-yl]-hept-6-ynyl}-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: dipotassium peroxodisulfate; copper(ll) sulfate pentahydrate / water; acetonitrile / 0.67 h / Heating / reflux

2.1: sodium ethanolate / ethanol / 48 h / 20 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

4.1: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

5.1: ethyloxirane; acetonitrile / 15 h / Heating / reflux

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

8.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 10 °C

9.1: pyridine N-oxide; sodium hydrogencarbonate / toluene / 24 h / Heating / reflux

10.1: potassium carbonate / methanol / 0 - 20 °C

11.1: water; sodium hydroxide / ethanol / 5 h / 20 °C

11.2: Acidic aqueous solution

12.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 5 h / 70 °C

12.2: 20 °C

13.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 78 °C

With pyridine N-oxide; dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tetrabutyl ammonium fluoride; water; hydrogen; sodium ethanolate; sodium hydrogencarbonate; potassium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethyloxirane; methanol; ethanol; dichloromethane; water; ethyl acetate; chlorobenzene; toluene; acetonitrile; 2.1: Horner-Wadsworth-Emmons Olefination / 4.1: Wittig Reaction / 5.1: Wittig Reaction / 10.1: Ohira alkynylation / 12.1: Sonogashira Coupling / 13.1: Suzuki Coupling;

Reference yield:

: 810681-06-2
3-bromo-5-iodobenzoyl chloride

: 1162261-49-5
4-[2-(2-carboxy-ethyl)-3-{7-[5-dimethylcarbamoyl-3'-fluoro-biphenyl-3-yl]-hept-6-ynyl}-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 5 h / 70 °C

2.2: 20 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 78 °C

With potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; 2.1: Sonogashira Coupling / 3.1: Suzuki Coupling;