1-[3-(p-acetyl-o-methoxyphenoxy)propyl]-4-[α,α-bis(p-fluorophenyl)methyl]piperidine

Base Information

• Chemical Name: 1-[3-(p-acetyl-o-methoxyphenoxy)propyl]-4-[α,α-bis(p-fluorophenyl)methyl]piperidine
• CAS No.: 60284-72-2
• Molecular Formula: C₃₀H₃₃F₂NO₃
• Molecular Weight: 493.594

Synonyms:1-[3-(p-acetyl-o-methoxyphenoxy)propyl]-4-[α,α-bis(p-fluorophenyl)methyl]piperidine

Chemical Property of 1-[3-(p-acetyl-o-methoxyphenoxy)propyl]-4-[α,α-bis(p-fluorophenyl)methyl]piperidine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-[3-(p-acetyl-o-methoxyphenoxy)propyl]-4-[α,α-bis(p-fluorophenyl)methyl]piperidine

There total 3 articles about 1-[3-(p-acetyl-o-methoxyphenoxy)propyl]-4-[α,α-bis(p-fluorophenyl)methyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(bis(4-fluorophenyl)methylene)piperidine (58113-36-3) → 1-[3-(p-acetyl-o-methoxyphenoxy)propyl]-4-[α,α-bis(p-fluorophenyl)methyl]piperidine (60284-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: I₂, phosphorous, methanesulfonic acid / aq. acetic acid / 7 h / Heating

2: K₂CO₃, KI / butan-1-ol / Heating

With phosphorus; methanesulfonic acid; iodine; potassium carbonate; potassium iodide; In acetic acid; butan-1-ol;

DOI:10.1021/jm00114a009

Reference yield:

4-(3-chloropropoxy)-3-methoxyacetophenone (58113-30-7) + 4-[bis(4-fluorophenyl)-methyl]piperidine (60285-00-9) → 1-[3-(p-acetyl-o-methoxyphenoxy)propyl]-4-[α,α-bis(p-fluorophenyl)methyl]piperidine (60284-72-2)

Guidance literature:

With potassium carbonate; potassium iodide; In butan-1-ol; Heating;

DOI:10.1021/jm00114a009

Reference yield:

→ 1-[3-(p-acetyl-o-methoxyphenoxy)propyl]-4-[α,α-bis(p-fluorophenyl)methyl]piperidine (60284-72-2)

Guidance literature:

entspr. Piperidin-Verb., 4-(3-Chlorpropoxy)-3-methoxy-acetophenon;

upstream raw materials:

4-(3-chloropropoxy)-3-methoxyacetophenone

4-[bis(4-fluorophenyl)-methyl]piperidine

4-(bis(4-fluorophenyl)methylene)piperidine

Downstream raw materials:

4-<3-<4--1-piperidinyl>propoxy>-3-methoxy-α-methylbenzenemethanol

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