3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazole-1-carbothioamide

Base Information

• Chemical Name: 3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazole-1-carbothioamide
• CAS No.: 1196987-70-8
• Molecular Formula: C₂₂H₂₁N₃O₄S
• Molecular Weight: 423.492
• Mol file: 1196987-70-8.mol

Synonyms:3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazole-1-carbothioamide

Chemical Property of 3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazole-1-carbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazole-1-carbothioamide

There total 4 articles about 3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazole-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

curcumin (458-37-7) + thiosemicarbazide (79-19-6) → 3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazole-1-carbothioamide (1196987-70-8)

Guidance literature:

With acetic acid; at 65 - 70 ℃; for 7h;

DOI:10.1016/j.ejmech.2012.05.020

Reference yield: 48.5%

(1E,6E)-4-chloro-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione + thiosemicarbazide (79-19-6) → 3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazole-1-carbothioamide (1196987-70-8)

Guidance literature:

With acetic acid; for 20h; Reflux;

DOI:10.21608/EJCHEM.2021.49070.3005

Reference yield:

3-chloropentane-2,4-dione (1694-29-7) → 3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazole-1-carbothioamide (1196987-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron trioxide / 1 h

1.2: 80 °C

2.1: acetic acid / 20 h / Reflux

With boron trioxide; acetic acid; 1.1: |Aldol Addition / 1.2: |Aldol Condensation;

DOI:10.21608/EJCHEM.2021.49070.3005

upstream raw materials:

curcumin

thiosemicarbazide

3-chloropentane-2,4-dione

vanillin