(2R,5S)-2-(1-oxoethyl)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran

Base Information

Chemical Name:(2R,5S)-2-(1-oxoethyl)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran
CAS No.:473535-34-1
Molecular Formula:C₂₃H₃₀O₃Si
Molecular Weight:382.575
Hs Code.:

Synonyms:(2R,5S)-2-(1-oxoethyl)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5S)-2-(1-oxoethyl)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran

Chemical Property:

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Technology Process of (2R,5S)-2-(1-oxoethyl)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran

There total 6 articles about (2R,5S)-2-(1-oxoethyl)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 917-64-6
methyl magnesium iodide

: 149198-05-0
(2R,5S)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran-2-carbonitrile

: 473535-34-1
(2R,5S)-2-(1-oxoethyl)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran

Guidance literature:: In diethyl ether; at 0 ℃; for 6h;
DOI:10.1021/jo016246j

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 473535-34-1
(2R,5S)-2-(1-oxoethyl)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole

2: diisobutylaluminium hydride / CH₂Cl₂ / 2 h / -78 °C

3: triethylamine; DMAP / CH₂Cl₂ / 3 h

4: 1.70 g / tin(IV) chloride / CH₂Cl₂ / 0.5 h / 0 °C

5: 83 percent / diethyl ether / 6 h / 0 °C

With 1H-imidazole; dmap; tin(IV) chloride; diisobutylaluminium hydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jo016246j

Reference yield:

: 21461-84-7
(2S)-tetrahydro-5-oxofuran-2-carboxylic acid

: 473535-34-1
(2R,5S)-2-(1-oxoethyl)-5-([(1,1-dimethyl)ethyldiphenylsilyl]oxymethyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 6 steps

1: BH₃-DMS

2: imidazole

3: diisobutylaluminium hydride / CH₂Cl₂ / 2 h / -78 °C

4: triethylamine; DMAP / CH₂Cl₂ / 3 h

5: 1.70 g / tin(IV) chloride / CH₂Cl₂ / 0.5 h / 0 °C

6: 83 percent / diethyl ether / 6 h / 0 °C

With 1H-imidazole; dmap; dimethylsulfide borane complex; tin(IV) chloride; diisobutylaluminium hydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jo016246j