methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[4-hydroxy-3-(hydroxymethyl)phenyl]propanoate

Base Information

Chemical Name:methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[4-hydroxy-3-(hydroxymethyl)phenyl]propanoate
CAS No.:1228019-38-2
Molecular Formula:C₁₆H₂₃NO₆
Molecular Weight:325.362
Hs Code.:

Synonyms:methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[4-hydroxy-3-(hydroxymethyl)phenyl]propanoate

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Chemical Property of methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[4-hydroxy-3-(hydroxymethyl)phenyl]propanoate

Chemical Property:

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Technology Process of methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[4-hydroxy-3-(hydroxymethyl)phenyl]propanoate

There total 1 articles about methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[4-hydroxy-3-(hydroxymethyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1228019-37-1
(S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3-(hydroxy-methyl)phenyl)propanoicacid

: 74-88-4
methyl iodide

: 1228019-38-2
methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[4-hydroxy-3-(hydroxymethyl)phenyl]propanoate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 45h;
DOI:10.1021/jm301610q

Reference yield: 83.0%

: 1228019-38-2
methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[4-hydroxy-3-(hydroxymethyl)phenyl]propanoate

: 106-95-6
allyl bromide

: 1228019-39-3
C₁₉H₂₇NO₆

Guidance literature:: With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ol100692x

Reference yield:

: 1228019-38-2
methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[4-hydroxy-3-(hydroxymethyl)phenyl]propanoate

: 1427289-20-0
C₃₅H₃₃N₂O₁₀P

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / dichloromethane / 3 h / -60 - 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

4: chlorotriisopropylsilane; trifluoroacetic acid / water

With chlorotriisopropylsilane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301610q