methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate

Base Information

Chemical Name:methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate
CAS No.:1313358-47-2
Molecular Formula:C₃₉H₆₀N₆O₉
Molecular Weight:756.94
Hs Code.:

methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate

Synonyms:methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate

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Chemical Property of methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate

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Technology Process of methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate

There total 11 articles about methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82625-45-4
4-(2-morpholin-4-yl-ethoxy)-benzaldehyde

: 1313358-47-2
methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropyl alcohol / 20 °C / Reflux

2.1: hydrogen / palladium on carbon / ethanol / 20 °C / Inert atmosphere

3.1: isopropyl alcohol / 12 h / Reflux

4.1: hydrogenchloride; water / tetrahydrofuran / 4 h / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane; N,N-dimethyl-formamide / 0 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: C₃₁H₄₇N₅O₆*(x)ClH

: 198904-78-8
methyl (S)-(1-hydrazinyl-3,3-dimethyl-1-oxobutan-2-yl)carbamate

: 1313358-47-2
methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate

Guidance literature:: methyl (S)-(1-hydrazinyl-3,3-dimethyl-1-oxobutan-2-yl)carbamate; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

C₃₁H₄₇N₅O₆*(x)ClH; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 20859-02-3
L-tert-Leucine

: 1313358-47-2
methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 18 h / 60 °C / pH 8 - 9

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / ethyl acetate / 0 °C

2.2: 18 h / 20 °C

3.1: hydrogenchloride; water / 1,4-dioxane / 12 h / 0 - 20 °C

4.1: isopropyl alcohol / 20 °C / Reflux

5.1: hydrogen / palladium on carbon / ethanol / 20 °C / Inert atmosphere

6.1: isopropyl alcohol / 12 h / Reflux

7.1: hydrogenchloride; water / tetrahydrofuran / 4 h / Reflux

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane; N,N-dimethyl-formamide / 0 °C / Inert atmosphere

8.2: 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;