3-(3-cyanophenyl)-5-N-[2'-aminosulfonyl-[1,1']-biphenyl-4-yl]aminocarbonyl-5-carbomethoxy methyl-isoxazoline

Base Information

Chemical Name:3-(3-cyanophenyl)-5-N-[2'-aminosulfonyl-[1,1']-biphenyl-4-yl]aminocarbonyl-5-carbomethoxy methyl-isoxazoline
CAS No.:193006-36-9
Molecular Formula:C₂₆H₂₂N₄O₆S
Molecular Weight:518.55
Hs Code.:

Synonyms:3-(3-cyanophenyl)-5-N-[2'-aminosulfonyl-[1,1']-biphenyl-4-yl]aminocarbonyl-5-carbomethoxy methyl-isoxazoline

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Chemical Property of 3-(3-cyanophenyl)-5-N-[2'-aminosulfonyl-[1,1']-biphenyl-4-yl]aminocarbonyl-5-carbomethoxy methyl-isoxazoline

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Technology Process of 3-(3-cyanophenyl)-5-N-[2'-aminosulfonyl-[1,1']-biphenyl-4-yl]aminocarbonyl-5-carbomethoxy methyl-isoxazoline

There total 8 articles about 3-(3-cyanophenyl)-5-N-[2'-aminosulfonyl-[1,1']-biphenyl-4-yl]aminocarbonyl-5-carbomethoxy methyl-isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 193006-35-8
5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester

: 193006-36-9
3-(3-cyanophenyl)-5-N-[2'-aminosulfonyl-[1,1']-biphenyl-4-yl]aminocarbonyl-5-carbomethoxy methyl-isoxazoline

Guidance literature:: With trifluoroacetic acid; for 0.5h; Heating;
DOI:10.1021/jm980405i

Reference yield:

: 7338-27-4
4-methoxy-2-methylene-4-oxobutanoic acid

: 193006-36-9
3-(3-cyanophenyl)-5-N-[2'-aminosulfonyl-[1,1']-biphenyl-4-yl]aminocarbonyl-5-carbomethoxy methyl-isoxazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / aq. bleach / tetrahydrofuran / 12 h / Ambient temperature

2: SOCl₂ / acetonitrile / 1 h / Heating

3: Et₃N / tetrahydrofuran / 0.5 h / Ambient temperature

4: 99 percent / TFA / 0.5 h / Heating

With sodium hypochlorite; thionyl chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm980405i

Reference yield:

: 150691-04-6
2-(tert-butylamino)sulfonylphenylboronic acid

: 193006-36-9
3-(3-cyanophenyl)-5-N-[2'-aminosulfonyl-[1,1']-biphenyl-4-yl]aminocarbonyl-5-carbomethoxy methyl-isoxazoline

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / Pd(PPh₃)4, tetrabutylammonium bromide, aq. Na₂CO₃ / benzene / 5.5 h / Heating

2: Et₃N / tetrahydrofuran / 0.5 h / Ambient temperature

3: 99 percent / TFA / 0.5 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; benzene;
DOI:10.1021/jm980405i