193006-35-8Relevant academic research and scientific papers
ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS
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Page/Page column 17, (2010/02/06)
Isoxazolines, isothiazolines and pyrazolines which are inhibitors of Factor Xa, pharmaceutical compositions containing these compounds, and methods of using these compounds as anticoagulant agents for treatment and prevention of thromboembolic disorders.
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1
Quan, Mimi L.,Liauw, Ann Y.,Ellis, Christopher D.,Pruitt, James R.,Carini, David J.,Bostrom, Lori L.,Huang, Peggy P.,Harrison, Kimberly,Knabb, Robert M.,Thoolen, Martin J.,Wong, Pancras C.,Wexler, Ruth R.
, p. 2752 - 2759 (2007/10/03)
Thrombosis is a major cause of mortality in the industrialized world. Therefore, the prevention of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (FXa), the enzyme directly re
ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR XA INHIBITORS
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, (2008/06/13)
Isoxazolines, isothiazolines and pyrazolines which are inhibitors of Factor Xa, pharmaceutical compositions containing these compounds, and methods of using these compounds as anticoagulant agents for treatment and prevention of thromboembolic disorders. The compounds can be represented by the formula: STR1 where X is O, S or NR 15.
