N-hydroxy-6-{[{[(4-methylphenyl)sulfonyl]amino}(phenyl)acetyl]amino}-1-benzothiophene-2-carboxamide

Base Information

Chemical Name:N-hydroxy-6-{[{[(4-methylphenyl)sulfonyl]amino}(phenyl)acetyl]amino}-1-benzothiophene-2-carboxamide
CAS No.:913653-80-2
Molecular Formula:C₂₄H₂₁N₃O₅S₂
Molecular Weight:495.58
Hs Code.:

Synonyms:N-hydroxy-6-{[{[(4-methylphenyl)sulfonyl]amino}(phenyl)acetyl]amino}-1-benzothiophene-2-carboxamide

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Chemical Property of N-hydroxy-6-{[{[(4-methylphenyl)sulfonyl]amino}(phenyl)acetyl]amino}-1-benzothiophene-2-carboxamide

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Technology Process of N-hydroxy-6-{[{[(4-methylphenyl)sulfonyl]amino}(phenyl)acetyl]amino}-1-benzothiophene-2-carboxamide

There total 4 articles about N-hydroxy-6-{[{[(4-methylphenyl)sulfonyl]amino}(phenyl)acetyl]amino}-1-benzothiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.3%

: C₂₅H₂₂N₂O₅S₂

: 913653-80-2
N-hydroxy-6-{[{[(4-methylphenyl)sulfonyl]amino}(phenyl)acetyl]amino}-1-benzothiophene-2-carboxamide

Guidance literature:: With hydroxylamine; In water; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide;

Reference yield:

: 34084-88-3
methyl 6-nitrobenzo[b]thiophene--2--carboxylate

: 913653-80-2
N-hydroxy-6-{[{[(4-methylphenyl)sulfonyl]amino}(phenyl)acetyl]amino}-1-benzothiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 96 h / 20 °C

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 42.5 h

3: hydroxylamine / water; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide

With dmap; hydrogen; hydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In water; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide;

Reference yield:

: 528-75-6
2,4-dinitrobenzaldehyde

: 913653-80-2
N-hydroxy-6-{[{[(4-methylphenyl)sulfonyl]amino}(phenyl)acetyl]amino}-1-benzothiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 - 50 °C

2: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 96 h / 20 °C

3: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 42.5 h

4: hydroxylamine / water; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide

With dmap; hydrogen; hydroxylamine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In water; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide;