ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate

Base Information

Chemical Name:ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate
CAS No.:1257388-52-5
Molecular Formula:C₂₄H₂₈F₂N₂O₄
Molecular Weight:446.494
Hs Code.:

Synonyms:ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate

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Chemical Property of ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate

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Technology Process of ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate

There total 3 articles about ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1257388-03-6
2-bromo-1-(3,5-difluoro-phenyl)-ethanone-oxime

: 1257388-50-3
ethyl (rac)-benzylamino(tetrahydropyran-4-yl)acetate

: 1257388-52-5
ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 220607-75-0
2-bromo-1-(3,5-difluorophenyl)ethanone

: 1257388-52-5
ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / methanol; water / 20 °C

2: potassium carbonate / tetrahydrofuran / 20 °C

With hydroxylamine hydrochloride; potassium carbonate; In tetrahydrofuran; methanol; water;

Reference yield:

: 646055-93-8
ethyl aminotetrahydropyran-4-ylacetate

: 100-39-0
benzyl bromide

: 1257388-52-5
ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

2: potassium carbonate / tetrahydrofuran / 20 °C

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;