3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)pyridine-4-carboxylic acid amide

Base Information

Chemical Name:3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)pyridine-4-carboxylic acid amide
CAS No.:1610889-71-8
Molecular Formula:C₂₀H₂₃F₃N₂OS
Molecular Weight:396.477
Hs Code.:

Synonyms:3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)pyridine-4-carboxylic acid amide

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Chemical Property of 3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)pyridine-4-carboxylic acid amide

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Technology Process of 3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)pyridine-4-carboxylic acid amide

There total 10 articles about 3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)pyridine-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 107-85-7
1-amino-3-methylbutane

: 1610889-93-4
3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid

: 1610889-71-8
3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)pyridine-4-carboxylic acid amide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 23 ℃; for 3h;

Reference yield:

: 66267-03-6
acetic acid [3-(4-fluorophenyl)-3-oxopropyl] ester

: 1610889-71-8
3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)pyridine-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 6 h / 0 - 20 °C

2.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

3.1: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

5.1: N,N-dimethyl-formamide / 1.5 h / 60 °C

6.1: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

7.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C / Sealed tube

8.1: water; sodium hydroxide / ethanol / 1 h / 80 °C

9.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C

9.2: 3 h / 0 - 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; boron trifluoride diethyl etherate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1242643-02-2
acetic acid 2-[2-(4-fluorophenyl)-[1,3]dithiolan-2-yl]ethyl ester

: 1610889-71-8
3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)pyridine-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

2.1: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 1.5 h / 60 °C

5.1: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C / Sealed tube

7.1: water; sodium hydroxide / ethanol / 1 h / 80 °C

8.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C

8.2: 3 h / 0 - 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;