5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester

Base Information

Chemical Name:5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester
CAS No.:847778-81-8
Molecular Formula:C₂₅H₃₄N₂O₆Si
Molecular Weight:486.64
Hs Code.:

5-(2-<i>tert</i>-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester

Synonyms:5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester

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Chemical Property of 5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester

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Technology Process of 5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester

There total 6 articles about 5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 847778-79-4
(S)-2-((Z)-3-Amino-3-phenyl-acryloylamino)-3-tert-butoxy-propionic acid methyl ester

: 618884-57-4
methyl 2-oxo-4-(trimethylsilyl)-3-butynoate

: 847778-81-8
5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester

Guidance literature:: With zinc dibromide; In toluene; for 6h; Heating;
DOI:10.1021/jo048106q

Reference yield:

: 847778-78-3
3-tert-butoxy-2-(3-oxo-3-phenyl-propionylamino)-propionic acid methyl ester

: 847778-81-8
5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / NH₄OAc; AcOH / toluene / Heating

2: 64 percent / ZnBr₂ / toluene / 6 h / Heating

With ammonium acetate; acetic acid; zinc dibromide; In toluene; 2: Bohlmann-Rahtz reaction;
DOI:10.1021/jo048106q

Reference yield:

: 3741-66-0
Ethyl benzoyl carbonate

: 847778-81-8
5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.5 h / -70 - -65 °C

1.2: 70 percent / hexane; tetrahydrofuran / 0.33 h / -68 °C

2.1: 91 percent / triethylamine; CuI / CH₂Cl₂ / 20 °C

3.1: 58 percent / NH₄OAc; AcOH / toluene / Heating

4.1: 64 percent / ZnBr₂ / toluene / 6 h / Heating

With copper(l) iodide; ammonium acetate; acetic acid; triethylamine; zinc dibromide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; toluene; 4.1: Bohlmann-Rahtz reaction;
DOI:10.1021/jo048106q