847778-79-4

Upstream product

• 65-85-0 benzoic acid 
• 467217-77-2 S-ethyl 3-oxo-3-phenylpropanethioate 
• 17114-97-5 O-tert-butyl-L-serine methyl ester hydrochloride 
• 3741-66-0 Ethyl benzoyl carbonate 
• 847778-78-3 3-tert-butoxy-2-(3-oxo-3-phenyl-propionylamino)-propionic acid methyl ester 

Downstream Products

• 847778-83-0 5-(2-tert-butoxy-1-methoxycarbonyl-ethylthiocarbamoyl)-6-phenyl-pyridine-2-carboxylic acid methyl ester 
• 847778-82-9 5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-pyridine-2-carboxylic acid methyl ester 
• 847778-84-1 5-((R)-4-Methoxycarbonyl-4,5-dihydro-thiazol-2-yl)-6-phenyl-pyridine-2-carboxylic acid methyl ester 
• 847778-81-8 5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

One-pot multistep Bohlmann-Rahtz heteroannulation reactions: Synthesis of dimethyl sulfomycinamate

(Chemical Equation Presented) The synthesis of dimethyl sulfomycinamate, the acidic methanolysis product of the sulfomycin family of thiopeptide antibiotics, from methyl 2-oxo-4-(trimethylsilyl)but-3-ynoate is achieved in a 2,3,6-trisubstituted pyridine synthesis that proceeds with total regiocontrol in 13 steps by the Bohlmann-Rahtz heteroannulation of a 1-(oxazol-4-yl)enamine or in 12 steps and 9% yield by three-component cyclocondensation with N-[3-oxo-3-(oxazol-4-yl)propanoyl]serine and ammonia in ethanol.