Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Base Information

Chemical Name:Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate
CAS No.:187035-79-6
Molecular Formula:C8H6ClF3N2O2
Molecular Weight:254.596
Hs Code.:29335990
European Community (EC) Number:671-389-8
DSSTox Substance ID:DTXSID10381655
Nikkaji Number:J804.879G
Wikidata:Q72473869
Mol file:187035-79-6.mol

Synonyms:Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate;187035-79-6;ethyl2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate;5-Pyrimidinecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, ethyl ester;MFCD01312372;Ethyl 2-chloro-4-(trifluoromethyl)-pyrimidine-5-carboxylate;ethyl 2-chloro-4-(trifluoromethyl)pyrimidne-5-carboxylate;Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate,2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid ethyl ester;SCHEMBL1549128;AMY3052;DTXSID10381655;2-chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester;AKOS005064004;AB08490;AC-9379;CS-W005314;PS-6510;SB60538;187635-79-6;SY020014;A4139;FT-0643778;EN300-6738037;J-012027;Z1741959988;ethyl 2-chloro-4-trifluoromethyl-5-pyrimidine carboxylate;2-Chloro-4-trifluoromethylpyrimidine-5-carboxylic acid ethyl ester;ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate, AldrichCPR

Suppliers and Price of Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate
100mg
$ 75.00

SynQuest Laboratories
Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 97%
5 g
$ 65.00

SynQuest Laboratories
Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 97%
1 g
$ 25.00

Matrix Scientific
Ethyl 2-chloro-4-(trifluoromethyl)-pyrimidine-5-carboxylate 97%
10g
$ 588.00

Matrix Scientific
Ethyl 2-chloro-4-(trifluoromethyl)-pyrimidine-5-carboxylate 97%
1g
$ 93.00

Frontier Specialty Chemicals
Ethyl2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 98%
5g
$ 36.00

Frontier Specialty Chemicals
Ethyl2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 98%
1g
$ 12.00

Frontier Specialty Chemicals
Ethyl2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 98%
25g
$ 110.00

Crysdot
Ethyl2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 97%
25g
$ 191.00

Chemenu
Ethyl2-chloro-4-(trifluoromethyl)-pyrimidine-5-carboxylate 97%
10g
$ 114.00

Total 56 raw suppliers

Chemical Property of Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Chemical Property:

Appearance/Colour:liquid
Vapor Pressure:0mmHg at 25°C
Refractive Index:1.466
Boiling Point:336.18 °C at 760 mmHg
PKA:-5.61±0.29(Predicted)
Flash Point:157.116 °C
PSA：52.08000
Density:1.449 g/cm³
LogP:2.32550
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:254.0069896
Heavy Atom Count:16
Complexity:262

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C(N=C1C(F)(F)F)Cl
Uses Intermediate for life science products. Attributes For further information please contact us Contact

Technology Process of Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

There total 5 articles about Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate hydrate

: 187035-79-6
ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Guidance literature:: ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate hydrate; With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 70 ℃; for 1h;

With water; In toluene; at 40 ℃;

Reference yield:

: 571-55-1
ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

: 187035-79-6
ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / NaOEt / ethanol / Heating

2: POCl₃ / 1 h / Heating

With sodium ethanolate; trichlorophosphate; In ethanol; 1: Condensation / 2: Chlorination;
DOI:10.1021/jm0001626