Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate

Base Information

Chemical Name:Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate
CAS No.:154934-97-1
Molecular Formula:C8H7F3N2O3
Molecular Weight:236.15
Hs Code.:29335990
European Community (EC) Number:672-017-7
DSSTox Substance ID:DTXSID50371873
Wikidata:Q72471459
Mol file:154934-97-1.mol

Synonyms:154934-97-1;ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate;5-ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1h)-one;2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester;Ethyl 2-hydroxy-4-trifluoromethylpyrimidine-5-carboxylate;ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate;5-Ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1H)-one;ethyl 2-oxo-6-(trifluoromethyl)-1H-pyrimidine-5-carboxylate;Ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate;Ethyl 2-oxo-6-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate;2-Hydroxy-4-trifluoromethylpyrimidine-5-carboxylic acid ethyl ester;Maybridge1_003966;Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate, Ethyl 1,2-dihydro-2-oxo-4-(trifluoromethyl)pyrimidine-5-carboxylate;SCHEMBL4592592;HMS552M06;AMY3053;DTXSID50371873;2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxylicacidethylester;Ethyl 1,2-dihydro-2-oxo-4-(trifluoromethyl)pyrimidine-5-carboxylate;MFCD00052077;AKOS005257720;AKOS015892482;AKOS026675545;AS-5343;CCG-256415;PS-6509;SB57976;AC-26677;A3410;CS-0063212;FT-0620368;J-517467;5-ethoxycarbonyl-4-(trifluoromethyl)-1h-pyrimidin-2-one;ethyl 2-hydroxy-4-trifluoromethyl-5-pyrimidinecarboxylate;5-ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2-(1h)-one;ETHYL-2-HYDROXY-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLATE

Suppliers and Price of Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxylicAcidEthylEster
1g
$ 90.00

SynQuest Laboratories
5-Ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1H)-one
1 g
$ 32.00

Matrix Scientific
5-Ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1H)-one tech
5g
$ 67.00

Matrix Scientific
5-Ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1H)-one tech
1g
$ 19.00

Frontier Specialty Chemicals
Ethyl4-(trifluoromethyl)-2-hydroxypyrimidine-5-carboxylate 97%
1g
$ 46.00

Crysdot
Ethyl2-hydroxy-4-trifluoromethylpyrimidine-5-carboxylate 95+%
5g
$ 60.00

Crysdot
Ethyl2-hydroxy-4-trifluoromethylpyrimidine-5-carboxylate 95+%
10g
$ 100.00

Crysdot
Ethyl2-hydroxy-4-trifluoromethylpyrimidine-5-carboxylate 95+%
100g
$ 600.00

Crysdot
Ethyl2-hydroxy-4-trifluoromethylpyrimidine-5-carboxylate 95+%
25g
$ 200.00

Chemenu
5-Ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1H)-one 95%
100g
$ 561.00

Total 40 raw suppliers

Chemical Property of Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate

Chemical Property:

Vapor Pressure:2.27E-06mmHg at 25°C
Melting Point:165 °C
Refractive Index:1.499
Boiling Point:381.7 °C at 760 mmHg
PKA:5.03±0.10(Predicted)
Flash Point:184.6 °C
PSA：72.05000
Density:1.508 g/cm³
LogP:0.96540
Storage Temp.:2-8°C
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:236.04087658
Heavy Atom Count:16
Complexity:385

Purity/Quality:

99%, ^*data from raw suppliers

2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=O)N=C1)C(F)(F)F

Technology Process of Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate

There total 4 articles about Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 122-51-0
orthoformic acid triethyl ester

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

: 57-13-6
urea

: 154934-97-1
ethyl 2-hydroxy-4-trifluoromethylpyrimidine-5-carboxylate

Guidance literature:: orthoformic acid triethyl ester; ethyl 4,4,4-trifluoroacetoacetate; urea; In ethanol; at 80 ℃; for 4h;

With sodium ethanolate; In ethanol; at 20 ℃; for 2.25h;

With acetic acid; In ethanol; at 20 - 30 ℃;