Imidazo[1,2-a]pyridine-6-carbaldehyde

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-6-carbaldehyde
• CAS No.: 116355-16-9
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60428180
• Nikkaji Number: J1.638.151I
• Wikidata: Q72482511
• Mol file: 116355-16-9.mol

Synonyms:Imidazo[1,2-a]pyridine-6-carbaldehyde;116355-16-9;Imidazo[1,2-a]pyridine-6-carboxaldehyde;MFCD07772808;6-imidazo[1,2-a]pyridinecarbaldehyde;6-FORMYLIMIDAZO[1,2-A]PYRIDINE;SCHEMBL308042;DTXSID60428180;VDWYLKPRUHCLAW-UHFFFAOYSA-N;AKOS006238131;6-imidazo[1,2-a]-pyridinecarbaldehyde;PB22050;AS-41611;SY104068;AM20050690;CS-0049337;FT-0652020;EN300-66951;Imidazo[1,2-a]pyridine-6-carboxaldehyde, 97%;Imidazo[1,2-a]pyridine-6-carbaldehyde, AldrichCPR;W-204899

Chemical Property of Imidazo[1,2-a]pyridine-6-carbaldehyde

Chemical Property:

• Melting Point: 152 °C
• Refractive Index: 1.641
• PKA: 5.27±0.50(Predicted)
• PSA: 34.37000
• Density: 1.25 g/cm³
• LogP: 1.14680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 146.048012819
• Heavy Atom Count: 11
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

Imidazo[1,2-a]pyridine-6-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22-43
• Safety Statements: 26-36/37/39-22-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=CN2C=C1C=O

Technology Process of Imidazo[1,2-a]pyridine-6-carbaldehyde

There total 8 articles about Imidazo[1,2-a]pyridine-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

6-(hydroxymethyl)imidazo[1,2-a]pyridine (132213-07-1) → 6-imidazo<1,2-a>pyridinecarboxaldehyde (116355-16-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 5h; Reflux;

DOI:10.1016/j.bmcl.2011.07.117

Reference yield: 62.0%

6-bromoimidazo[1,2-a]pyridine (6188-23-4) → 6-imidazo<1,2-a>pyridinecarboxaldehyde (116355-16-9)

Guidance literature:

With n-butyllithium; In methanol; ice-water; hexane; N,N-dimethyl-formamide;

Reference yield: 17.2%

methyl 6-imidazo<1,2-a>pyridinecarboxylate (136117-69-6) → 6-imidazo<1,2-a>pyridinecarboxaldehyde (116355-16-9)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -60 ℃;

DOI:10.1248/cpb.39.1556

upstream raw materials:

methyl 6-imidazo<1,2-a>pyridinecarboxylate

6-(hydroxymethyl)imidazo[1,2-a]pyridine

imidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester

ethyl-6-amino-nicotinate

Downstream raw materials:

6-difluoromethylimidazo[1,2-a]pyridine

olprinone

(Z)-ethyl α-[(triphenylphosphoranylidene)amino]-β-(imidazo[1,2-a]pyridin-6-yl)propenoate

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