Ethyl 6-aminonicotinate

Base Information

• Chemical Name: Ethyl 6-aminonicotinate
• CAS No.: 39658-41-8
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2933399090
• Mol file: 39658-41-8.mol

Synonyms:Nicotinicacid, 6-amino-, ethyl ester (7CI);2-Amino-5-(ethoxycarbonyl)pyridine;2-Amino-5-carbethoxypyridine;6-Aminonicotinic acid ethyl ester;6-Aminopyridine-3-carboxylic acid ethyl ester;Ethyl6-amino-3-pyridinecarboxylate;NSC 37818;

Chemical Property of Ethyl 6-aminonicotinate

Chemical Property:

• Vapor Pressure: 0.000457mmHg at 25°C
• Melting Point: 145-147 °C
• Boiling Point: 314.7 °C at 760 mmHg
• PKA: 4.88±0.13(Predicted)
• Flash Point: 144.1 °C
• PSA: 65.21000
• Density: 1.192 g/cm³
• LogP: 1.42170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl6-aminonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 6-aminonicotinate

There total 12 articles about Ethyl 6-aminonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

6-aminonicotinic acid (3167-49-5) + ethanol (64-17-5) → ethyl-6-amino-nicotinate (39658-41-8)

Guidance literature:

6-aminonicotinic acid; ethanol; With thionyl chloride; for 72h; Heating;

With sodium hydroxide; In methanol; for 1h;

DOI:10.1016/j.bmc.2003.12.039

Reference yield: 92.0%

6-aminonicotinic acid (3167-49-5) → ethyl-6-amino-nicotinate (39658-41-8)

Guidance literature:

In ethanol;

Reference yield: 65.0%

2-[1-(5-Ethoxycarbonyl-pyridin-2-ylamino)-meth-(Z)-ylidene]-succinic acid diethyl ester (69142-56-9) → ethyl-6-amino-nicotinate (39658-41-8) + 3-Ethoxycarbonylmethyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-7-carboxylic acid ethyl ester (70906-36-4)

Guidance literature:

With PPA; trichlorophosphate;

upstream raw materials:

6-aminonicotinic acid

ethanol

6-aminonicotinic amide

2-[1-(5-Ethoxycarbonyl-pyridin-2-ylamino)-meth-(Z)-ylidene]-succinic acid diethyl ester

Downstream raw materials:

Ethyl 2-methyl-3-ethyl-4-oxo-4H-pyrido<1,2-a>pyrimidine-7-carboxylate hydrochloride

(6-amino-3-pyridinyl)methanol

6-[bis-(biphenyl-2-carbonyl)-amino]-nicotinic acid ethyl ester

6-[bis-(2-chloro-4-fluoro-benzoyl)-amino]-nicotinic acid ethyl ester

Refernces

• 1、 -. "SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS". Paragraph 0841; 0842. . Retrieved 2017/04/04.
• 2、 -. "ISOPROPYL TRIAZOLO PYRIDINE COMPOUNDS". Paragraph 0042-0043. . Retrieved 2016/12/01.