Chemical Property of Motesanib
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:1.669
- Boiling Point:517.258 °C at 760 mmHg
- PKA:11.75±0.40(Predicted)
- Flash Point:266.628 °C
- PSA：78.94000
- Density:1.251 g/cm3
- LogP:4.32810
- Storage Temp.:Refrigerator
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- XLogP3:3.9
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:373.19026037
- Heavy Atom Count:28
- Complexity:533
- Purity/Quality:
-
99%, *data from raw suppliers
Motesanib *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
- Recent ClinicalTrials:AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors
- Recent EU Clinical Trials:A Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial
- Recent NIPH Clinical Trials:None
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Uses
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively. Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
