2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile

Base Information

Chemical Name:2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile
CAS No.:872201-78-0
Molecular Formula:C₃₀H₃₁NO₄
Molecular Weight:469.58
Hs Code.:

Synonyms:2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile

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Chemical Property of 2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile

Chemical Property:

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Technology Process of 2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile

There total 2 articles about 2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 943638-31-1
2,3-O-isopropylidene-1-hydroxy-2-C-methyl-5-O-trityl-D-ribofuranose

: 2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-β-D-ribofuranosyl)acetonitrile

: 872201-78-0
2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile

Guidance literature:: diethyl 1-cyanomethylphosphonate; With sodium hydride; In 1,2-dimethoxyethane; at 0 ℃; for 0.166667h;

2,3-O-isopropylidene-1-hydroxy-2-C-methyl-5-O-trityl-D-ribofuranose; In 1,2-dimethoxyethane; at 20 ℃; for 4h; Further stages.;
DOI:10.1016/j.bmc.2007.05.020

Reference yield:

: 872201-77-9
C₃₁H₃₄O₅

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-β-D-ribofuranosyl)acetonitrile

: 872201-78-0
2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile

Guidance literature:: With sodium hydride; In 1,2-dimethoxyethane; at 0 ℃; for 4.16667h;

Reference yield:

: 872201-78-0
2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile

: 107-31-3
Methyl formate

: 872201-69-9
HOCHC₂N(CH₃)3C₆H₅O₄C(C₆H₅)3

Guidance literature:: 2-(2-C-methyl-2,3-O-(1-methylethylidene)-5-O-trityl-α-D-ribofuranosyl)acetonitrile; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

Methyl formate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Further stages.;
DOI:10.1016/j.bmc.2007.05.020