diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate

Base Information

Chemical Name:diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate
CAS No.:1646184-30-6
Molecular Formula:C₃₈H₃₈N₄O₅
Molecular Weight:630.744
Hs Code.:

Synonyms:diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate

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Chemical Property of diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate

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Technology Process of diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate

There total 4 articles about diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 5798-75-4
Ethyl 4-bromobenzoate

: 1623775-07-4
N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-4-methylbenzamide

: 1646184-09-9
ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’-biphenyl]-4-carboxylate

: 1646184-30-6
diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate

Guidance literature:: With tris(triphenylphosphine)ruthenium(II) chloride; sodium carbonate; In o-xylene; at 120 ℃; for 22h; chemoselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.201403019

Reference yield:

: 2978-58-7
1,1-dimethylprop-3-ynylamine

: 1646184-09-9
ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’-biphenyl]-4-carboxylate

: 1646184-30-6
diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Schlenk technique; Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

3: tris(triphenylphosphine)ruthenium(II) chloride; sodium carbonate / o-xylene / 22 h / 120 °C / Inert atmosphere; Schlenk technique

With tris(triphenylphosphine)ruthenium(II) chloride; copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; triethylamine; In dichloromethane; o-xylene; water; tert-butyl alcohol; 1: |Huisgen Cycloaddition;
DOI:10.1002/chem.201403019

Reference yield:

: 1310826-33-5
2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine

: 1646184-09-9
ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’-biphenyl]-4-carboxylate

: 1646184-30-6
diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: tris(triphenylphosphine)ruthenium(II) chloride; sodium carbonate / o-xylene / 22 h / 120 °C / Inert atmosphere; Schlenk technique

With tris(triphenylphosphine)ruthenium(II) chloride; sodium carbonate; triethylamine; In dichloromethane; o-xylene;
DOI:10.1002/chem.201403019