3-benzyloxy-2-iodo-4-methoxybenzyl alcohol

Base Information

• Chemical Name: 3-benzyloxy-2-iodo-4-methoxybenzyl alcohol
• CAS No.: 934389-25-0
• Molecular Formula: C₁₅H₁₅IO₃
• Molecular Weight: 370.187
• Mol file: 934389-25-0.mol

Synonyms:3-benzyloxy-2-iodo-4-methoxybenzyl alcohol

Chemical Property of 3-benzyloxy-2-iodo-4-methoxybenzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyloxy-2-iodo-4-methoxybenzyl alcohol

There total 1 articles about 3-benzyloxy-2-iodo-4-methoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-(benzyloxy)-2-iodo-4-methoxybenzaldehyde (151726-42-0) → 3-benzyloxy-2-iodo-4-methoxybenzyl alcohol (934389-25-0)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1016/j.tet.2007.01.021

Reference yield: 79.0%

3-benzyloxy-2-iodo-4-methoxybenzyl alcohol (934389-25-0) + dimethyl imidodicarboxylate (51216-94-5) → 3-benzyloxy-2-iodo-4-methoxy-N,N-di(methoxycarbonyl)benzylamine (934389-28-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃;

DOI:10.1016/j.tet.2007.01.021

Reference yield:

3-benzyloxy-2-iodo-4-methoxybenzyl alcohol (934389-25-0) → 2,3-dihydro-7-benzyloxy-6-methoxy-1H-isoindol-1-one

Guidance literature:

Multi-step reaction with 2 steps

1.1: 79 percent / DEAD; triphenylphosphine / toluene; tetrahydrofuran / 0 - 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / -90 - 20 °C

2.2: 64 percent / hexane; tetrahydrofuran / 0.5 h / Heating

With n-butyllithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; toluene; 1.1: Mitsunobu reaction;

DOI:10.1016/j.tet.2007.01.021

upstream raw materials:

3-(benzyloxy)-2-iodo-4-methoxybenzaldehyde

Downstream raw materials:

3-benzyloxy-2-iodo-4-methoxy-N,N-di(methoxycarbonyl)benzylamine