N,N',N''-[nitrilo(ethane-2,1-diyl)]tris[N-(3-hydroxypropyl)-4-methylbenzenesulfonamide]

Base Information

• Chemical Name: N,N',N''-[nitrilo(ethane-2,1-diyl)]tris[N-(3-hydroxypropyl)-4-methylbenzenesulfonamide]
• CAS No.: 180618-51-3
• Molecular Formula: C₃₆H₅₄N₄O₉S₃
• Molecular Weight: 783.044
• Mol file: 180618-51-3.mol

Synonyms:N,N',N''-[nitrilo(ethane-2,1-diyl)]tris[N-(3-hydroxypropyl)-4-methylbenzenesulfonamide]

Chemical Property of N,N',N''-[nitrilo(ethane-2,1-diyl)]tris[N-(3-hydroxypropyl)-4-methylbenzenesulfonamide]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N',N''-[nitrilo(ethane-2,1-diyl)]tris[N-(3-hydroxypropyl)-4-methylbenzenesulfonamide]

There total 2 articles about N,N',N''-[nitrilo(ethane-2,1-diyl)]tris[N-(3-hydroxypropyl)-4-methylbenzenesulfonamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-[[2-(Bis-{2-[(2-methoxycarbonyl-ethyl)-(toluene-4-sulfonyl)-amino]-ethyl}-amino)-ethyl]-(toluene-4-sulfonyl)-amino]-propionic acid methyl ester (180618-50-2) → N,N',N''-[nitrilo(ethane-2,1-diyl)]tris[N-(3-hydroxypropyl)-4-methylbenzenesulfonamide] (180618-51-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1002/hlca.19960790302

Reference yield:

tris[2-(N-tosylaminoethyl)]amine (98846-92-5) → N,N',N''-[nitrilo(ethane-2,1-diyl)]tris[N-(3-hydroxypropyl)-4-methylbenzenesulfonamide] (180618-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / acetonitrile / 12 h / Ambient temperature

2: 83 percent / LiAlH₄ / tetrahydrofuran / 24 h / Ambient temperature

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1002/hlca.19960790302

Reference yield: 98.0%

methanesulfonyl chloride (124-63-0) + N,N',N''-[nitrilo(ethane-2,1-diyl)]tris[N-(3-hydroxypropyl)-4-methylbenzenesulfonamide] (180618-51-3) → Methanesulfonic acid 3-[[2-(bis-{2-[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-ethyl}-amino)-ethyl]-(toluene-4-sulfonyl)-amino]-propyl ester

Guidance literature:

With triethylamine; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1002/hlca.19960790302

upstream raw materials:

3-[[2-(Bis-{2-[(2-methoxycarbonyl-ethyl)-(toluene-4-sulfonyl)-amino]-ethyl}-amino)-ethyl]-(toluene-4-sulfonyl)-amino]-propionic acid methyl ester

tris[2-(N-tosylaminoethyl)]amine