Dovitinib

Base Information

• Chemical Name: Dovitinib
• CAS No.: 915769-50-5
• Molecular Formula: C21H21FN6O^.C3H6O3^.H2O
• Molecular Weight: 500.53
• Mol file: 915769-50-5.mol

Synonyms:4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-hydroxypropanoate hydrate (1:1:1);

Chemical Property of Dovitinib

Chemical Property:

• PSA: 160.80000
• LogP: 2.51610
• Solubility.: insoluble in EtOH; ≥10.62 mg/mL in DMSO; ≥168.2 mg/mL in H2O

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate is a useful research chemical compound.

Technology Process of Dovitinib

There total 1 articles about Dovitinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one DL-lactic acid salt (692737-80-7,852433-84-2) → 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one mono 2-hydroxypropanoate hydrate (915769-50-5)

Guidance literature:

With water; In ethanol; at 20 ℃; for 42h; Purification / work up;

upstream raw materials:

4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one DL-lactic acid salt

Refernces