TKI 258

Base Information

• Chemical Name: TKI 258
• CAS No.: 692737-80-7
• Molecular Formula: C24H27FN6O4
• Molecular Weight: 482.5073832
• Hs Code.: 2914500090
• Mol file: 692737-80-7.mol

Synonyms:CHIR-258 lactate;CHIR-258, TKI-258;Dovitinib lactate;Dovitinib Lactate Salt;TKI 258 Dovitinib Lactate;Dovitinib (CHIR-258) lactate;CHIR-258 LACTATE; TKI-258 LACTATE;Propanoic acid, 2-hydroxy-, coMpd. with 4-aMino-5-fluoro-3-[6-(4;4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo-[d]imidazol-2-yl)quinolin-2(1H)-one 2-;4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo-[d]imidazol-2-yl)quinolin-2(1H)-one 2-hyd

Chemical Property of TKI 258

Chemical Property:

• PSA: 151.57000
• LogP: 2.58040
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

DovitinibLactate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dovitinib is used in treating melanoma.

Technology Process of TKI 258

There total 7 articles about TKI 258 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one (405169-16-6,804551-71-1) + LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) → 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one DL-lactic acid salt (692737-80-7,852433-84-2)

Guidance literature:

In ethanol; water; at 68 - 72 ℃; for 0.25 - 0.75h;

Reference yield:

1-methyl-piperazine (109-01-3) → 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one DL-lactic acid salt (692737-80-7,852433-84-2)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 20 - 100 °C

2: hydrogen / 5%-palladium/activated carbon / ethanol; water / 40 - 55 °C

3: 0.25 h / 40 - 55 °C

4: potassium hexamethylsilazane / tetrahydrofuran / 0.67 - 1.08 h / 38 - 63 °C

5: ethanol; water / 0.25 - 0.75 h / 68 - 72 °C

With hydrogen; potassium hexamethylsilazane; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; water;

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one DL-lactic acid salt (692737-80-7,852433-84-2)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 20 - 100 °C

2: hydrogen / 5%-palladium/activated carbon / ethanol; water / 40 - 55 °C

3: 0.25 h / 40 - 55 °C

4: potassium hexamethylsilazane / tetrahydrofuran / 0.67 - 1.08 h / 38 - 63 °C

5: ethanol; water / 0.25 - 0.75 h / 68 - 72 °C

With hydrogen; potassium hexamethylsilazane; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; water;

upstream raw materials:

4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one

LACTIC ACID

1-methyl-piperazine

[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]acetic acid ethyl ester

Downstream raw materials:

dovitinib dilactic acid

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