3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid

Base Information

Chemical Name:3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid
CAS No.:865620-66-2
Molecular Formula:C₂₀H₁₇ClF₂N₂O₄S₂
Molecular Weight:486.948
Hs Code.:

Synonyms:3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid

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Chemical Property of 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid

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Technology Process of 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid

There total 1 articles about 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 865620-65-1
3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester

: 865620-66-2
3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid

Guidance literature:: 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; water; pH=1;

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 865620-66-2
3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid

: 4-Chloro-N-(2,5-difluoro-phenyl)-N-{1-[5-(3-morpholin-4-yl-3-oxo-propyl)-thiazol-2-yl]-ethyl}-benzenesulfonamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h;

Reference yield:

: 865620-66-2
3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid

: 4-Chloro-N-(2,5-difluoro-phenyl)-N-{1-[5-(3-oxo-propyl)-thiazol-2-yl]-ethyl}-benzenesulfonamide

: 4-Chloro-N-(2,5-difluoro-phenyl)-N-{1-[5-(3-hydroxy-propyl)-thiazol-2-yl]-ethyl}-benzenesulfonamide

Guidance literature:: 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid; With diisobutylaluminium hydride; In tetrahydrofuran; at -78 - 20 ℃;

With rochelle salt; In tetrahydrofuran; water;