3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester

Base Information

Chemical Name:3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester
CAS No.:865620-65-1
Molecular Formula:C₂₁H₁₉ClF₂N₂O₄S₂
Molecular Weight:500.975
Hs Code.:

Synonyms:3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester

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Chemical Property of 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester

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Technology Process of 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester

There total 1 articles about 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 290331-05-4
4-chloro-N-[5-fluoro-2-fluorophenyl]benzenesulfonamide

: 865620-64-0
3-[2-(1-hydroxy-ethyl)-thiazol-5-yl]-propionic acid methyl ester

: 865620-65-1
3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 ℃; for 16h;

Reference yield: 77.0%

: 865620-65-1
3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester

: 865620-66-2
3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acid

Guidance literature:: 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; water; pH=1;

Reference yield:

: 865620-65-1
3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester

: 75-16-1
methylmagnesium bromide

: 4-Chloro-N-(2,5-difluoro-phenyl)-N-{1-[5-(3-hydroxy-3-methyl-butyl)-thiazol-2-yl]-ethyl}-benzene sulfonamide

Guidance literature:: 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

With ammonium chloride; In tetrahydrofuran; diethyl ether; water;