Methanesulfonic acid (1R,2S)-2-((R)-3-benzyloxy-1-methyl-propyl)-cyclopropylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,2S)-2-((R)-3-benzyloxy-1-methyl-propyl)-cyclopropylmethyl ester
CAS No.:1027248-91-4
Molecular Formula:C₁₆H₂₄O₄S
Molecular Weight:312.43
Hs Code.:

Synonyms:Methanesulfonic acid (1R,2S)-2-((R)-3-benzyloxy-1-methyl-propyl)-cyclopropylmethyl ester

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Chemical Property of Methanesulfonic acid (1R,2S)-2-((R)-3-benzyloxy-1-methyl-propyl)-cyclopropylmethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Methanesulfonic acid (1R,2S)-2-((R)-3-benzyloxy-1-methyl-propyl)-cyclopropylmethyl ester

There total 12 articles about Methanesulfonic acid (1R,2S)-2-((R)-3-benzyloxy-1-methyl-propyl)-cyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 182949-22-0
[(1R,2S)-2-((R)-3-Benzyloxy-1-methyl-propyl)-cyclopropyl]-methanol

: 1027248-91-4
Methanesulfonic acid (1R,2S)-2-((R)-3-benzyloxy-1-methyl-propyl)-cyclopropylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1039/p19960002291

Reference yield:

: 144781-81-7
methyl (3S,4R)-4-(tert-butyldimethylsiloxy)-3,7-dimethyl-6-octenoate

: 1027248-91-4
Methanesulfonic acid (1R,2S)-2-((R)-3-benzyloxy-1-methyl-propyl)-cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

2: 100 percent / NaH / dimethylformamide / 2 h / Ambient temperature

3: 1.) O₃, 2.) PPh₃ / 1.) MeOH, -78 deg C, 10 min, 2.) -78 deg C to r.t.

4: 87 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

5: 99 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

6: 86 percent / dimethylsulfoxide / 6 h / 60 °C

7: 99 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

8: 86 percent / KO-t-Bu / tetrahydrofuran / 2 h / Ambient temperature

9: 94 percent / DIBAL / tetrahydrofuran; hexane / 2 h / -78 °C

10: 96 percent / NaBH₄ / tetrahydrofuran / 12 h / Ambient temperature

11: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride; diisobutylaluminium hydride; ozone; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/p19960002291

Reference yield:

: 144781-72-6
(1R,2R,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(1-chloro-1-methyl-ethyl)-2-methyl-cyclopentanecarboxylic acid methyl ester

: 1027248-91-4
Methanesulfonic acid (1R,2S)-2-((R)-3-benzyloxy-1-methyl-propyl)-cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: SmI₂ / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature

2: 93 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

3: 100 percent / NaH / dimethylformamide / 2 h / Ambient temperature

4: 1.) O₃, 2.) PPh₃ / 1.) MeOH, -78 deg C, 10 min, 2.) -78 deg C to r.t.

5: 87 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

6: 99 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

7: 86 percent / dimethylsulfoxide / 6 h / 60 °C

8: 99 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

9: 86 percent / KO-t-Bu / tetrahydrofuran / 2 h / Ambient temperature

10: 94 percent / DIBAL / tetrahydrofuran; hexane / 2 h / -78 °C

11: 96 percent / NaBH₄ / tetrahydrofuran / 12 h / Ambient temperature

12: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; samarium diiodide; potassium tert-butylate; sodium hydride; diisobutylaluminium hydride; ozone; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/p19960002291