4-(2-chloroethyl)-2-(4-methoxybenzyl)-3-oxo-3,4-dihydroquinoxaline 1-oxide

Base Information

Chemical Name:4-(2-chloroethyl)-2-(4-methoxybenzyl)-3-oxo-3,4-dihydroquinoxaline 1-oxide
CAS No.:1610961-27-7
Molecular Formula:C₁₈H₁₇ClN₂O₃
Molecular Weight:344.798
Hs Code.:

Synonyms:4-(2-chloroethyl)-2-(4-methoxybenzyl)-3-oxo-3,4-dihydroquinoxaline 1-oxide

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Chemical Property of 4-(2-chloroethyl)-2-(4-methoxybenzyl)-3-oxo-3,4-dihydroquinoxaline 1-oxide

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Technology Process of 4-(2-chloroethyl)-2-(4-methoxybenzyl)-3-oxo-3,4-dihydroquinoxaline 1-oxide

There total 4 articles about 4-(2-chloroethyl)-2-(4-methoxybenzyl)-3-oxo-3,4-dihydroquinoxaline 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1610961-20-0
4-(2-chloroethyl)-2-cyano-3-oxo-3,4-dihydroquinoxaline 1-oxide

: 38769-92-5
4-methoxybenzylmagnesium chloride

: 1610961-27-7
4-(2-chloroethyl)-2-(4-methoxybenzyl)-3-oxo-3,4-dihydroquinoxaline 1-oxide

Guidance literature:: In tetrahydrofuran; at -40 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.03.061

Reference yield:

: 122-98-5
2-Anilinoethanol

: 1610961-27-7
4-(2-chloroethyl)-2-(4-methoxybenzyl)-3-oxo-3,4-dihydroquinoxaline 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride; N,N-dimethyl-formamide / toluene / 5 h / 0 - 80 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

3: sodium nitrite; sulfuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 5 h / 0 - 20 °C

4: tetrahydrofuran / 18 h / -40 °C / Inert atmosphere

With thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sulfuric acid; triethylamine; N,N-dimethyl-formamide; sodium nitrite; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2014.03.061

Reference yield:

: 935-06-8
N-(2-chloroethyl)aniline

: 1610961-27-7
4-(2-chloroethyl)-2-(4-methoxybenzyl)-3-oxo-3,4-dihydroquinoxaline 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: sodium nitrite; sulfuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 5 h / 0 - 20 °C

3: tetrahydrofuran / 18 h / -40 °C / Inert atmosphere

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sulfuric acid; triethylamine; sodium nitrite; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2014.03.061