2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-ethano-1H-3-benzazepin-2-one

Base Information

Chemical Name:2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-ethano-1H-3-benzazepin-2-one
CAS No.:136005-59-9
Molecular Formula:C₂₀H₂₁NO₃
Molecular Weight:323.392
Hs Code.:

Synonyms:2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-ethano-1H-3-benzazepin-2-one

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Chemical Property of 2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-ethano-1H-3-benzazepin-2-one

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Technology Process of 2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-ethano-1H-3-benzazepin-2-one

There total 9 articles about 2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-ethano-1H-3-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 136005-60-2
ethyl 6,7,8,9-tetrahydro-8-hydroxyimino-2,3-dimethoxy-5-phenyl-5H-benzocyclohepten-5-carboxylate

: 136005-59-9
2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-ethano-1H-3-benzazepin-2-one

Guidance literature:: With sodium hydroxide; nickel; In ethanol; water; for 1.5h; Ambient temperature;

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 136005-59-9
2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-ethano-1H-3-benzazepin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 1) 98percent H₂SO₄, gl. acetic acid / 1) 70 deg C, 1.5 h, 2) reflux, overnight

2: 1) EtONa, 2) hexamethylphosphoramide / 1) THF, 0.5 h, 2) THF, rt, overnight

3: 73 percent / NaOH / ethanol; H₂O / Heating

4: 60 percent / polyphosphoric acid / 6 h / Ambient temperature

5: 56 percent / BuLi / tetrahydrofuran / Heating

6: 23 percent / AgNO₃, I₂ / methanol; H₂O / 0.5 h / Heating

7: 95 percent / NH₂OH*HCl, pyridine / ethanol / 3 h / Heating

8: 40 percent / NaOH / Raney alloy / ethanol; H₂O / 1.5 h / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; PPA; sulfuric acid; hydroxylamine hydrochloride; iodine; sodium ethanolate; silver nitrate; acetic acid; nickel; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 2897-71-4
ethyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxylate

: 136005-59-9
2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-ethano-1H-3-benzazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 56 percent / BuLi / tetrahydrofuran / Heating

2: 23 percent / AgNO₃, I₂ / methanol; H₂O / 0.5 h / Heating

3: 95 percent / NH₂OH*HCl, pyridine / ethanol / 3 h / Heating

4: 40 percent / NaOH / Raney alloy / ethanol; H₂O / 1.5 h / Ambient temperature

With pyridine; sodium hydroxide; n-butyllithium; hydroxylamine hydrochloride; iodine; silver nitrate; nickel; In tetrahydrofuran; methanol; ethanol; water;