Technology Process of 2-carbobenzoxy-1,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline
There total 7 articles about 2-carbobenzoxy-1,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 0.166667h;
Ambient temperature;
DOI:10.1248/cpb.40.1993
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 61 percent / CH3COONH4 / acetic acid / 1.5 h / Heating
2: LiAlH4 / tetrahydrofuran; diethyl ether / 0.83 h / Heating
3: 76 percent / 10percent NaOH / CH2Cl2 / 0.5 h / Ambient temperature
4: 98 percent / 4-dimethylaminopyridine / acetonitrile / 67 h / Ambient temperature
5: 1.) OsO4, pyridine, 2.) sodium hydrogen sulfite / 1.) RT, 3.5 h, 2.) water, RT, 2.5 h
6: 76 percent / NaIO4 / methanol; H2O / 0.08 h / Ambient temperature
7: 100 percent / K2CO3 / dimethylformamide / 2 h / 40 °C
8: 86 percent / TFA / CH2Cl2 / 0.17 h / Ambient temperature
With
pyridine; dmap; sodium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; sodium hydrogensulfite; trifluoroacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.40.1993
- Guidance literature:
-
Multi-step reaction with 7 steps
1: LiAlH4 / tetrahydrofuran; diethyl ether / 0.83 h / Heating
2: 76 percent / 10percent NaOH / CH2Cl2 / 0.5 h / Ambient temperature
3: 98 percent / 4-dimethylaminopyridine / acetonitrile / 67 h / Ambient temperature
4: 1.) OsO4, pyridine, 2.) sodium hydrogen sulfite / 1.) RT, 3.5 h, 2.) water, RT, 2.5 h
5: 76 percent / NaIO4 / methanol; H2O / 0.08 h / Ambient temperature
6: 100 percent / K2CO3 / dimethylformamide / 2 h / 40 °C
7: 86 percent / TFA / CH2Cl2 / 0.17 h / Ambient temperature
With
pyridine; dmap; sodium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; potassium carbonate; sodium hydrogensulfite; trifluoroacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.40.1993
