Technology Process of 7,8-diMethoxy-1,2,3,4-tetrahydroisoquinoline
There total 17 articles about 7,8-diMethoxy-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
ethanol;
Ambient temperature;
DOI:10.1248/cpb.46.918
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
acetic acid;
under 760 Torr;
Ambient temperature;
DOI:10.1248/cpb.40.1993
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 61 percent / CH3COONH4 / acetic acid / 1.5 h / Heating
2: LiAlH4 / tetrahydrofuran; diethyl ether / 0.83 h / Heating
3: 76 percent / 10percent NaOH / CH2Cl2 / 0.5 h / Ambient temperature
4: 98 percent / 4-dimethylaminopyridine / acetonitrile / 67 h / Ambient temperature
5: 1.) OsO4, pyridine, 2.) sodium hydrogen sulfite / 1.) RT, 3.5 h, 2.) water, RT, 2.5 h
6: 76 percent / NaIO4 / methanol; H2O / 0.08 h / Ambient temperature
7: 100 percent / K2CO3 / dimethylformamide / 2 h / 40 °C
8: 86 percent / TFA / CH2Cl2 / 0.17 h / Ambient temperature
9: H2 / 10percent Pd/C / acetic acid / 760 Torr / Ambient temperature
With
pyridine; dmap; sodium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; ammonium acetate; hydrogen; potassium carbonate; sodium hydrogensulfite; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.40.1993
