5-(2-chlorophenyl)-2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxide

Base Information

• Chemical Name: 5-(2-chlorophenyl)-2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxide
• CAS No.: 1064667-42-0
• Molecular Formula: C₁₇H₁₄ClN₃O
• Molecular Weight: 311.771
• Mol file: 1064667-42-0.mol

Synonyms:5-(2-chlorophenyl)-2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxide

Chemical Property of 5-(2-chlorophenyl)-2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-(2-chlorophenyl)-2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxide

There total 2 articles about 5-(2-chlorophenyl)-2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-(2-chlorophenyl)-N-(3-((2-nitrophenyl)amino)propyl)acetamide → 5-(2-chlorophenyl)-2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxide (1064667-42-0)

Guidance literature:

With ethyl polyphosphate (PPE); Microwave irradiation; Reflux;

DOI:10.1016/j.molstruc.2010.07.050

Reference yield:

N1-(2-nitrophenyl)propane-1,3-diamine (145315-42-0) + 2-(2-chlorophenyl)acetyl chloride (51512-09-5) → 5-(2-chlorophenyl)-2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxide (1064667-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / chloroform / 0.25 h

2: ethyl polyphosphate / 5 h / Reflux

With sodium hydroxide; In chloroform;

DOI:10.1021/jo502626f

Reference yield:

5-(2-chlorophenyl)-2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxide (1064667-42-0) + dimethyl sulfoxide (67-68-5,8070-53-9) → C18H17ClN3O

Guidance literature:

With Fenton reagent; In aq. phosphate buffer; pH=7.6; Kinetics;

DOI:10.1039/c4ra14335c

upstream raw materials:

N₁-(2-nitrophenyl)propane-1,3-diamine

2-(2-chlorophenyl)acetyl chloride