(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

Base Information

• Chemical Name: (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester
• CAS No.: 468741-39-1
• Molecular Formula: C₂₄H₂₄ClN₅O₃
• Molecular Weight: 465.939
• Mol file: 468741-39-1.mol

Synonyms:(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

Chemical Property of (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

There total 10 articles about (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile (468734-63-6) + ethanol (64-17-5) → (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester (468741-39-1)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/j.bmcl.2007.03.048

Reference yield:

N-(4-cyano-2-methyl-6-nitro-phenyl)-2,2,2-trifluoro-acetamide (468741-01-7) → (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester (468741-39-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / NH₃ / methanol

2: 90 percent / SnCl₂*2H₂O / ethanol / Heating

3: 46 percent / I₂ / methanol

4: 100 percent / HCl / dioxane; H₂O

5: 94 percent / Et₃N / dimethylformamide / 80 °C

6: 90 percent / HCl

With hydrogenchloride; ammonia; iodine; triethylamine; tin(ll) chloride; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.03.048

Reference yield:

N-(4-cyano-2-methylphenyl)-2,2,2-trifluoroacetamide (943634-40-0) → (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester (468741-39-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 52 percent / KNO₃; conc. sulfuric acid

2: 95 percent / NH₃ / methanol

3: 90 percent / SnCl₂*2H₂O / ethanol / Heating

4: 46 percent / I₂ / methanol

5: 100 percent / HCl / dioxane; H₂O

6: 94 percent / Et₃N / dimethylformamide / 80 °C

7: 90 percent / HCl

With hydrogenchloride; sulfuric acid; ammonia; iodine; potassium nitrate; triethylamine; tin(ll) chloride; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.03.048

upstream raw materials:

(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile

ethanol

N-(4-cyano-2-methylphenyl)-2,2,2-trifluoroacetamide

N-(4-cyano-2-methyl-6-nitro-phenyl)-2,2,2-trifluoro-acetamide

Downstream raw materials:

(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboxylic acid ethyl ester

Refernces

• 1、 -. "Novel tyrosine kinase inhibitors". Page 134. . Retrieved 2010/11/30.