(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

Base Information

Chemical Name:(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester
CAS No.:468741-39-1
Molecular Formula:C₂₄H₂₄ClN₅O₃
Molecular Weight:465.939
Hs Code.:

Synonyms:(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

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Chemical Property of (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

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Technology Process of (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

There total 10 articles about (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 468734-63-6
(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile

: 64-17-5
ethanol

: 468741-39-1
(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

Guidance literature:: With hydrogenchloride;
DOI:10.1016/j.bmcl.2007.03.048

Reference yield:

: 468741-01-7
N-(4-cyano-2-methyl-6-nitro-phenyl)-2,2,2-trifluoro-acetamide

: 468741-39-1
(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / NH₃ / methanol

2: 90 percent / SnCl₂*2H₂O / ethanol / Heating

3: 46 percent / I₂ / methanol

4: 100 percent / HCl / dioxane; H₂O

5: 94 percent / Et₃N / dimethylformamide / 80 °C

6: 90 percent / HCl

With hydrogenchloride; ammonia; iodine; triethylamine; tin(ll) chloride; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.048

Reference yield:

: 943634-40-0
N-(4-cyano-2-methylphenyl)-2,2,2-trifluoroacetamide

: 468741-39-1
(+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 52 percent / KNO₃; conc. sulfuric acid

2: 95 percent / NH₃ / methanol

3: 90 percent / SnCl₂*2H₂O / ethanol / Heating

4: 46 percent / I₂ / methanol

5: 100 percent / HCl / dioxane; H₂O

6: 94 percent / Et₃N / dimethylformamide / 80 °C

7: 90 percent / HCl

With hydrogenchloride; sulfuric acid; ammonia; iodine; potassium nitrate; triethylamine; tin(ll) chloride; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.048