10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione

Base Information

• Chemical Name: 10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione
• CAS No.: 185435-45-4
• Molecular Formula: C₂₈H₂₂F₃N₃O₂
• Molecular Weight: 490.489

Synonyms:10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione

Chemical Property of 10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione

Chemical Property:

Purity/Quality:

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Technology Process of 10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione

There total 8 articles about 10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-benzoic acid ethyl ester (443-26-5) → 10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-2H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (185435-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1: LiAlD₄ / diethyl ether

2: pyridinium chlorochromate / CH₂Cl₂

3: dimethylformamide / 6 h / 100 °C

With lithium aluminium deuteride; pyridinium chlorochromate; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo961799t

Reference yield:

1-<2-(trifluoromethyl)phenyl>urea (13114-85-7) → 10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-2H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (185435-45-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / NaOMe / methanol / 16 h / Heating

2: 72 percent / POCl₃ / H₂O / 28 h / 60 °C

3: 76 percent / butan-1-ol / 3 h / Heating

4: dimethylformamide / 6 h / 100 °C

With sodium methylate; trichlorophosphate; In methanol; water; N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1021/jo961799t

Reference yield:

2-fluoro-<α,α-2H2>benzyl alcohol (127530-30-7) → 10-(4-tert-butylphenyl)-3-[2-(trifluoromethyl)phenyl][5-2H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (185435-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium chlorochromate / CH₂Cl₂

2: dimethylformamide / 6 h / 100 °C

With pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo961799t

upstream raw materials:

2-fluoro-<α-²H>benzaldehyde

6-(4-tert-Butyl-phenylamino)-3-(2-trifluoromethyl-phenyl)-1H-pyrimidine-2,4-dione

2-fluoro-benzoic acid ethyl ester

4-tert-Butylaniline

Downstream raw materials:

3-(2-{[(tert-butyldimethylsilyl)oxy][²H₂]methyl}phenyl)-10-(4-tert-butylphenyl)[5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione

C₂₈H₂₄⁽²⁾H₃N₃O₃

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