4-{4-methyl-2-[(S)-2-methyl-1-(2-methyl-propane-2-sulfonylamino)-propyl]-phenyl}-piperazine-1-carboxylic aicd tert-butyl ester

Base Information

Chemical Name:4-{4-methyl-2-[(S)-2-methyl-1-(2-methyl-propane-2-sulfonylamino)-propyl]-phenyl}-piperazine-1-carboxylic aicd tert-butyl ester
CAS No.:869478-60-4
Molecular Formula:C₂₄H₄₁N₃O₄S
Molecular Weight:467.673
Hs Code.:

Synonyms:4-{4-methyl-2-[(S)-2-methyl-1-(2-methyl-propane-2-sulfonylamino)-propyl]-phenyl}-piperazine-1-carboxylic aicd tert-butyl ester

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Chemical Property of 4-{4-methyl-2-[(S)-2-methyl-1-(2-methyl-propane-2-sulfonylamino)-propyl]-phenyl}-piperazine-1-carboxylic aicd tert-butyl ester

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Technology Process of 4-{4-methyl-2-[(S)-2-methyl-1-(2-methyl-propane-2-sulfonylamino)-propyl]-phenyl}-piperazine-1-carboxylic aicd tert-butyl ester

There total 5 articles about 4-{4-methyl-2-[(S)-2-methyl-1-(2-methyl-propane-2-sulfonylamino)-propyl]-phenyl}-piperazine-1-carboxylic aicd tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 851484-99-6
4-{4-methyl-2-[(S)-2-methyl-1-((S_S)-2-methyl-propane-2-sulfinylamino)-propyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

: 869478-60-4
4-{4-methyl-2-[(S)-2-methyl-1-(2-methyl-propane-2-sulfonylamino)-propyl]-phenyl}-piperazine-1-carboxylic aicd tert-butyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.75h;
DOI:10.1021/jo051514p

Reference yield:

: 93249-44-6
2-fluoro-5-methylbenzaldehyde

: 869478-60-4
4-{4-methyl-2-[(S)-2-methyl-1-(2-methyl-propane-2-sulfonylamino)-propyl]-phenyl}-piperazine-1-carboxylic aicd tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / K₂CO₃ / N,N-dimethyl-acetamide / 22 h / 155 °C

2: 99 percent / Ti(OEt)4 / tetrahydrofuran; ethanol / 16 h / 20 °C

3: 71 percent / Me₃Al / tetrahydrofuran; pentane; heptane / 1 h / -68 °C

4: 100 percent / m-CPBA / CH₂Cl₂ / 0.75 h / 20 °C

With titanium(IV) tetraethanolate; trimethylaluminum; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; N,N-dimethyl acetamide; pentane;
DOI:10.1021/jo051514p

Reference yield:

: 851753-68-9
4-(2-formyl-4-methyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 869478-60-4
4-{4-methyl-2-[(S)-2-methyl-1-(2-methyl-propane-2-sulfonylamino)-propyl]-phenyl}-piperazine-1-carboxylic aicd tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / Ti(OEt)4 / tetrahydrofuran; ethanol / 16 h / 20 °C

2: 71 percent / Me₃Al / tetrahydrofuran; pentane; heptane / 1 h / -68 °C

3: 100 percent / m-CPBA / CH₂Cl₂ / 0.75 h / 20 °C

With titanium(IV) tetraethanolate; trimethylaluminum; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; pentane;
DOI:10.1021/jo051514p