(9H-fluoren-9-yl)methyl (R,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate

Base Information

Chemical Name:(9H-fluoren-9-yl)methyl (R,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate
CAS No.:881920-81-6
Molecular Formula:C₃₁H₄₃NO₂Si
Molecular Weight:489.773
Hs Code.:

Synonyms:(9H-fluoren-9-yl)methyl (R,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate

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Chemical Property of (9H-fluoren-9-yl)methyl (R,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate

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Technology Process of (9H-fluoren-9-yl)methyl (R,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate

There total 11 articles about (9H-fluoren-9-yl)methyl (R,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 881920-77-0
((R,E)-1-isocyanato-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)allyl)-trimethylsilane

: 24324-17-2
9-Fluorenylmethanol

: 881920-81-6
(9H-fluoren-9-yl)methyl (R,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate

Guidance literature:: With titanium(IV) tetrabutoxide; In benzene; at 45 ℃; for 3h;
DOI:10.1021/ol053061g

Reference yield:

: ((E)-1-isocyanato-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)allyl)-trimethylsilane

: 24324-17-2
9-Fluorenylmethanol

: (9H-fluoren-9-yl)methyl (S,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate

: 881920-81-6
(9H-fluoren-9-yl)methyl (R,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate

Guidance literature:: With titanium(IV) tetrabutoxide; In benzene; at 45 ℃; for 3h; Title compound not separated from byproducts;
DOI:10.1021/ol053061g

Reference yield:

: 70737-22-3
((E)-2-iodoethenyl)(trimethyl)silane

: 881920-81-6
(9H-fluoren-9-yl)methyl (R,E)-3-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-(trimethylsilyl)allylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tert-butyllithium / diethyl ether; pentane / -78 - 23 °C

1.2: 40 percent / diethyl ether; pentane / 3 h / -78 °C

2.1: 67 percent / N-methylmorpholine N-oxide; tetrapropylammonium perruthenate; molecular sieves 4 Angstroem / CH₂Cl₂ / 0.58 h / 20 °C

3.1: lithium triethylborohydride / tetrahydrofuran / 0.33 h / -78 °C

4.1: CH₂Cl₂ / 1 h / 0 °C

5.1: 268 mg / potassium carbonate / methanol; H₂O / 0 - 23 °C

6.1: trifluoroacetic anhydride; triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

7.1: 70 percent / titanium(IV) tert-butoxide / benzene / 3 h / 45 °C

With titanium(IV) tetrabutoxide; tetrapropylammonium perruthennate; 4 A molecular sieve; tert.-butyl lithium; lithium triethylborohydride; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; pentane; benzene;
DOI:10.1021/ol053061g