2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester

Base Information

Chemical Name:2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester
CAS No.:404890-59-1
Molecular Formula:C₁₉H₂₆O₄
Molecular Weight:318.413
Hs Code.:

Synonyms:2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester

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Chemical Property of 2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester

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Technology Process of 2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester

There total 7 articles about 2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97518-80-4
benzyl 2,2-dimethyl-3-oxopropanoate

: 404890-59-1
2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: (+)-Ipc₂BOMe / diethyl ether / 3 h / -78 - 20 °C

1.2: 79 percent / diethyl ether / 4 h / -78 °C

2.1: 83 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 1 h / 0 °C

3.1: 76 percent / Grubbs' imidazolidinyl ruthenium complex / CH₂Cl₂ / 4 h / 20 °C

4.1: 7 percent / NaBH₄ / NiCl₂*6H₂O / tetrahydrofuran / 2 h / 0 °C

5.1: 70 percent / acetonitrile / 24 h / 90 °C

6.1: t-BuOK / tetrahydrofuran / 0.33 h / -78 °C

With dmap; sodium tetrahydroborate; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; (+)-B-methoxydiisocamphenylborane; Grubbs catalyst first generation; nickel dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/ol016938u

Reference yield:

: 404890-49-9
(R)-3-Hydroxy-2,2-dimethyl-hex-5-enoic acid benzyl ester

: 404890-59-1
2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 1 h / 0 °C

2: 76 percent / Grubbs' imidazolidinyl ruthenium complex / CH₂Cl₂ / 4 h / 20 °C

3: 7 percent / NaBH₄ / NiCl₂*6H₂O / tetrahydrofuran / 2 h / 0 °C

4: 70 percent / acetonitrile / 24 h / 90 °C

5: t-BuOK / tetrahydrofuran / 0.33 h / -78 °C

With dmap; sodium tetrahydroborate; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; nickel dichloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol016938u

Reference yield:

: 404890-51-3
2-methyl-2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)-propionic acid benzyl ester

: 404890-59-1
2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 7 percent / NaBH₄ / NiCl₂*6H₂O / tetrahydrofuran / 2 h / 0 °C

2: 70 percent / acetonitrile / 24 h / 90 °C

3: t-BuOK / tetrahydrofuran / 0.33 h / -78 °C

With sodium tetrahydroborate; potassium tert-butylate; nickel dichloride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol016938u