97518-80-4

Upstream product

• 100-39-0 benzyl bromide 
• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 
• 17701-61-0 benzyl 2,2-dimethyl-3-hydroxypropanoic acid 

Downstream Products

• 876343-21-4 benzyl-2,2-dimethyl-3-piperidin-1-ylpropanoate 
• 1531585-26-8 benzyl 2-cyclopropyl-2-methylpropanoate 
• 1447942-30-4 benzyl 3,3-difluoro-2,2-dimethylpropanoate 
• 97519-34-1 2-(2-t-Butoxycarbonylaminothiazol-4-yl)-4-methyl-4-benzyloxycarbonyl-2-pentenoic acid 
• 404890-44-4 2-{(2R,6S)-6-[(2R,4R,5S)-7-((2S,6R)-6-Allyl-tetrahydro-pyran-2-yl)-2,4-dihydroxy-5-methyl-heptyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid benzyl ester 
• 404890-72-8 2-{(2R,6S)-6-[(4R,5S)-7-((2S,6R)-6-Allyl-tetrahydro-pyran-2-yl)-4-hydroxy-5-methyl-2-oxo-heptyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid benzyl ester 
• 404890-57-9 (E)-(R)-3-Hydroxy-2,2-dimethyl-9-oxo-dec-7-enoic acid benzyl ester 
• 404890-59-1 2-Methyl-2-[(2R,6R)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid benzyl ester 

Relevant academic research and scientific papers

ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK 1)

The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Synthesis of the spiroacetal core of the cephalosporolide family of natural products

The synthesis of four possible stereoisomers of the spiroacetal core of the natural products cephalosporolides H and I and penisporolides A and B is described. The key steps involve the use of Sharpless asymmetric dihydroxylation to install the desired stereochemistry of the γ-lactone ring and an oxidative radical cyclisation to form the spiroacetal ring system.

ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3?, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2

Preparation and synthetic applications of sterically hindered secondary amines

The preparation of sterically hindered secondary amino esters from the reaction of N-protected α-amino aldehydes and 3-, or 2-oxo esters with α- amino esters by reductive amination is described. The resulting amino esters were converted to the β-lactam or acylated to form N-acyl secondary amides.