3-Acetyl-6-methoxyindole

Base Information

• Chemical Name: 3-Acetyl-6-methoxyindole
• CAS No.: 99532-52-2
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• Hs Code.: 2933990090
• Mol file: 99532-52-2.mol

Synonyms:1-(6-methoxy-1H-indol-3-yl)ethanone;

Chemical Property of 3-Acetyl-6-methoxyindole

Chemical Property:

• PSA: 42.09000
• LogP: 2.37910
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

1-(6-Methoxy-1H-indol-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Acetyl-6-methoxyindole

There total 14 articles about 3-Acetyl-6-methoxyindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-methoxylindole (3189-13-7) + acetyl chloride (75-36-5) → 1-(6-methoxy-1H-indol-3-yl)ethan-1-one (99532-52-2)

Guidance literature:

6-methoxylindole; With diethylaluminium chloride; In hexane; dichloromethane; at 0 ℃; for 0.5h;

acetyl chloride; In hexane; dichloromethane; at 50 ℃; for 0.166667h; Further stages.; microwave irradiation;

DOI:10.1016/j.bmcl.2008.03.089

Reference yield: 92.0%

3-(6-methoxy-1H-indol-3-yl)-3-oxopropanenitrile (1082892-90-7) → 1-(6-methoxy-1H-indol-3-yl)ethan-1-one (99532-52-2)

Guidance literature:

With sodium hydroxide; In water; for 4h; Reflux;

DOI:10.2174/157017811799304395

Reference yield: 91.0%

C15H18F3NO5 → 1-(6-methoxy-1H-indol-3-yl)ethan-1-one (99532-52-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 60 ℃;

DOI:10.1039/c7ob01536d

upstream raw materials:

1-(6-methoxy-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone

6-methoxy-1-(phenylsulfonyl)-1H-indole

2-(3-methoxyanilino)acetaldehyde diethyl acetal

N-(2,2-diethoxyethyl)-N-(3-methoxyphenyl)-benzene-sulfonamide

Downstream raw materials:

3-acetyl-1-(4-fluorobenzyl)-6-methoxy-1H-indole

C₁₈H₁₇NO₂

1-(6-methoxy-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone

3-acetyl-6-methoxy-N-(toluenesulfonyl)indole

Refernces

• 1、 Li, Wenlong,Shuai, Wen,Sun, Honghao,Xu, Feijie,Bi, Yi,Xu, Jinyi,Ma, Cong,Yao, Hequan,Zhu, Zheying,Xu, Shengtao. "Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site". . p. 428 - 442. Retrieved 2018/12/13.
• 2、 Borah, Arun Jyoti,Shi, Zhuangzhi. "Palladium-catalyzed regioselective C-H fluoroalkylation of indoles at the C4-position". supporting information. p. 3945 - 3948. Retrieved 2017/04/11.