2,4,5-trichlorophenyl 3,5-dimethyl-4-(2-t-butoxycarbonylaminoethyl)pyrrole-2-carboxylate

Base Information

Chemical Name:2,4,5-trichlorophenyl 3,5-dimethyl-4-(2-t-butoxycarbonylaminoethyl)pyrrole-2-carboxylate
CAS No.:83089-87-6
Molecular Formula:C₂₀H₂₃Cl₃N₂O₄
Molecular Weight:461.773
Hs Code.:

Synonyms:2,4,5-trichlorophenyl 3,5-dimethyl-4-(2-t-butoxycarbonylaminoethyl)pyrrole-2-carboxylate

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Chemical Property of 2,4,5-trichlorophenyl 3,5-dimethyl-4-(2-t-butoxycarbonylaminoethyl)pyrrole-2-carboxylate

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Technology Process of 2,4,5-trichlorophenyl 3,5-dimethyl-4-(2-t-butoxycarbonylaminoethyl)pyrrole-2-carboxylate

There total 6 articles about 2,4,5-trichlorophenyl 3,5-dimethyl-4-(2-t-butoxycarbonylaminoethyl)pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 4-(2-tert-Butoxycarbonylamino-ethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid

: 95-95-4
2,4,5-trichlorophenol

: 83089-87-6
2,4,5-trichlorophenyl 3,5-dimethyl-4-(2-t-butoxycarbonylaminoethyl)pyrrole-2-carboxylate

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 20h;

Reference yield:

: 20303-31-5
benzyl 4-(2-methoxycarbonylethyl)-3,5-dimethylpyrrole-2-carboxylate

: 83089-87-6
2,4,5-trichlorophenyl 3,5-dimethyl-4-(2-t-butoxycarbonylaminoethyl)pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / hydrazine hydrate / ethanol / 3 h / Heating

2: aq. HCl, NaNO₂ / H₂O / 0.5 h / 0 °C

3: benzene / 2 h / Heating

4: 63 percent / trifluoroacetic acid / benzene / 4 h / Heating

5: triethylamine, H₂ / Pd/C / tetrahydrofuran / 2 h

6: 76 percent / dicyclohexylcarbodi-imide / CH₂Cl₂ / 20 h / 0 °C

With hydrogenchloride; hydrogen; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; benzene;

Reference yield:

: 28844-01-1
benzyl 4-(2-hydrazidoethyl)-3,5-dimethylpyrrole-2-carboxylate

: 83089-87-6
2,4,5-trichlorophenyl 3,5-dimethyl-4-(2-t-butoxycarbonylaminoethyl)pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: aq. HCl, NaNO₂ / H₂O / 0.5 h / 0 °C

2: benzene / 2 h / Heating

3: 63 percent / trifluoroacetic acid / benzene / 4 h / Heating

4: triethylamine, H₂ / Pd/C / tetrahydrofuran / 2 h

5: 76 percent / dicyclohexylcarbodi-imide / CH₂Cl₂ / 20 h / 0 °C

With hydrogenchloride; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; benzene;