Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Chemical Name:Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
CAS No.:117824-83-6
Molecular Formula:C₄₀H₄₂N₃O₁₀P
Molecular Weight:755.761
Hs Code.:

Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Synonyms:Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 3 articles about Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17331-53-2
3'-O-benzoylthymidine

: 117824-83-6
Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / diisopropylamine hydrotetrazolide / CH₂Cl₂ / 1 h / 30 °C

2: 1H-tetrazole, I₂

With 1H-tetrazole; N,N-diisopropylamine tetrazolide; iodine; In dichloromethane;
DOI:10.1248/cpb.36.1386

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 117824-83-6
Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / diisopropylethylamine / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 1H-tetrazole, I₂

With 1H-tetrazole; iodine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1248/cpb.36.1386