113019-11-7

Upstream product

• 141-43-5 ethanolamine 
• 14470-28-1 mono-4-methoxytrityl chloride 

Downstream Products

• 89576-29-4 1-O-cis-octadec-9-enoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine 
• 13190-01-7 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine 
• 117854-43-0 Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-(diisopropylamino-methoxy-phosphanyloxy)-tetrahydro-furan-2-ylmethyl ester 2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl ester methyl ester 
• 117854-42-9 Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(diisopropylamino-methoxy-phosphanyloxy)-tetrahydro-furan-2-ylmethyl ester 2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl ester methyl ester 
• 117854-35-0 Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl ester methyl ester 
• 117854-40-7 Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl ester methyl ester 
• 117854-39-4 Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl ester methyl ester 
• 117854-34-9 Phosphoric acid (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl ester methyl ester 
• 269399-35-1 2-((4-methoxytrityl)amino)acetic aldehyde 
• 117824-86-9 Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester 
• 117824-85-8 Benzoic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester 
• 117824-83-6 Benzoic acid (2R,3S,5R)-2-[methoxy-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 113019-13-9 Phosphoric acid 2-chloro-phenyl ester 2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl ester; compound with triethyl-amine 

Relevant academic research and scientific papers

Monoclonal antibodies with affinity to self-complementary left-handed DNA containing cyclonucleosides with high anti conformation

Monoclonal antibodies specific for a self-complementary hexanucleotide with a high-anti conformation were found to bind another hexanucleotide with a high-anti conformation, but with a different sequence. A higher order structure seemed to be recognized i

Development of a 3′-amino linker with high conjugation activity and its application to conveniently cross-link blunt ends of a duplex

The 2-aminoethyl carbamate linker (ssH linker) exhibits high activity in modifying the 5′-termini of oligonucleotides; however, the ssH linker is not appropriate for 3′-terminal modification because it undergoes intramolecular trans-acylation under heat-a

MELANIN PRODUCTION INHIBITOR

Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor is represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent. At least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group. When one of R1 and R2 is an oxo group, the other is not present. R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms. The number of R3's present in the compound corresponds to X and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.

Oligonucleotide probe

An aminated oligonucleotide probe is provided, in which the amino group possesses improved reactivity. The present invention relates to an oligonucleotide probe, which is represented by general formula 1: (wherein R1 is a hydrogen atom or a pro

Novel amino linkers enabling efficient labeling and convenient purification of amino-modified oligonucleotides

We developed new amino linker reagents for an oligonucleotide (ONT) terminus. These reagents consist of an aminoethyl carbamate main linkage and a side-chain residue, which was a naphthylmethoxymethyl, methoxymethyl, or methyl group or a hydrogen atom. Th

Epoxidation of peptidyl olefin isosteres. Stereochemical induction effect of chiral centers at four adjacent C(α) positions

Four tripeptidyl olefin isosteres were prepared, each of which contains a single chiral center derived from the bulky amino acid phenylalanine at positions corresponding to the P2-P'2 positions of a protease substrate. The effect of these chiral centers on the stereochemical outcome of mCPBA epoxidation of the olefin functionality was studied. A chiral center at P2 or P'2 position has no significant effect, and the P'1 position exerts a small stereoselectivity. A chiral center at the P1 position, on the other hand, has a profound chiral induction effect on the epoxidation reaction. (C) 2000 Elsevier Science Ltd.

Synthesis of phospholipid-oligodeoxyribonucleotide conjugates

Chemical synthesis of modified phospholipids and their attachment to oligodeoxyribonucleotides via dithiolinker is described.

PHOSPHORYLATING AGENT FOR THE SYNTHESIS OF OLIGONUCLEOTIDE WITH ALIPHATIC AMINO GROUP AT 5' END

A lipophilic phosphorylating agent was prepared and used for the synthesis of pentadeoxyribonucleotide with aminoethyl group at 5' end on a polymer support by the phosphotriester method.