Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate

Base Information

Chemical Name:Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate
CAS No.:205676-76-2
Molecular Formula:C₂₂H₃₀F₃NO₇
Molecular Weight:477.478
Hs Code.:

Synonyms:Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate

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Chemical Property of Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate

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Technology Process of Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate

There total 5 articles about Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2-[1-(2-{[tert-Butoxycarbonyl-(2,2,2-trifluoro-ethyl)-amino]-methyl}-4-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid dimethyl ester

: 205676-76-2
Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm990446u

Reference yield:

: 6163-58-2
tris-(o-tolyl)phosphine

: 205676-74-0
(2-bromo-5-methoxy-benzyl)-(2,2,2-trifluoro-ethyl)-carbamic acid tert-butyl ester

: 205676-76-2
Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; palladium diacetate; In ethyl acetate; toluene; propiononitrile;

Reference yield:

: 27060-75-9
4-bromo-3-methylanisole

: 205676-76-2
Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-(2,2,2-trifluoroethyl)amino]methyl-4-methoxyphenyl]butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / NBS; (BzO)2 / CH₂Cl₂

2: 77 percent / dimethylformamide

3: 92 percent / Pd(OAc)2; P(o-tol)3; (iPr)2NEt / various solvent(s) / Heating

4: 90 percent / H₂ / Pd/C / ethyl acetate

With palladium diacetate; N-Bromosuccinimide; hydrogen; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; dibenzoyl peroxide; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Bromination / 2: Condensation / 3: Condensation / 4: Catalytic hydrogenation;
DOI:10.1021/jm990446u